Pollen-specific immunoglobulin E positivity is associated with worsening of depression scores in bipolar disorder patients during high pollen season.

Bipolar Disorders
Partam ManalaiTeodor T Postolache

Abstract

An association between allergic disease and depression has been consistently reported, but whether the key mediating ingredients are predominantly biological, psychological, or mere artifacts remains unknown. In the current study, we examined a hypothesized relationship between allergen-specific immunoglobulin E (IgE) status and changes in allergy symptoms with worsening in depression scores. In patients with recurrent mood disorders, we individually coupled sensitization to specific seasonal aeroallergens (as assessed by allergen-specific IgE) with temporal windows of exposure to aeroallergens (low versus high tree or ragweed pollen counts, measured according to the National Allergy Bureau guidelines). We compared Structured Interview Guide for the Hamilton Depression Rating Scale-Seasonal Affective Disorder Version (SIGH-SAD) depression score changes in 41 patients with mood disorders [25 with major depression and 16 with bipolar I disorder, diagnosed by Structured Clinical Interview for DSM (SCID)] seropositive for tree or ragweed pollen-specific IgE antibody versus 53 patients with mood disorders (30 with major depression and 23 with bipolar I disorder) seronegative for aeroallergen-specific IgE. Worsening in total depressi...Continue Reading

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Citations

Apr 4, 2012·International Journal of Environmental Research and Public Health·Jong-Min WooTeodor T Postolache
Feb 20, 2013·Expert Opinion on Therapeutic Targets·Murtada AlsaifSabine Bahn
Oct 2, 2015·Journal of Psychiatric Research·Eran Elhaik, Peter Zandi
Jul 27, 2014·Journal of Affective Disorders·Pierre Alexis GeoffroyBruno Etain
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Oct 28, 2014·AIMS Public Health·Olaoluwa OkusagaTeodor T Postolache
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Aug 6, 2018·The Science of the Total Environment·Ricardo AlmendraPaula Santana
Jun 29, 2021·Frontiers in Psychiatry·Teodor T PostolacheLisa A Brenner

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