Polo-like kinase 1 is essential to DNA damage recovery

Leukemia & Lymphoma
Lin LiuPing Zou

Abstract

Radiation treatment and chemotherapy can both cause DNA damage to tumor cells. Tumor cells have specific self-protecting mechanisms to escape death. In this study, we explored the effects of polo-like kinase 1 on the DNA damage recovery system in lymphoma cell lines. DNA damage caused inhibition of polo-like kinase 1 activity and induced cell cycle arrest at the G2/M phase. Once the DNA damage was repaired, polo-like kinase 1 activity was restored and cell cycle arrest was removed. Unexpectedly, polo-like kinase 1 depletion hampered the cell cycle progress of cells recovered from DNA damage, and induced apoptosis.

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Citations

May 30, 2013·Cancer Biotherapy & Radiopharmaceuticals·Julia Alejandra PezukLuiz Gonzaga Tone
Jan 24, 2019·Blood·Eline Pronk, Marc H G P Raaijmakers

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