PMID: 16627997Apr 22, 2006Paper

Polo-like kinases: a team in control of the division

Cell Cycle
Barbara C M van de Weerdt, René H Medema

Abstract

Polo, the founding member of the family of polo-like kinases (Plks) was identified in a Drosophila screen for mutants affecting spindle pole behavior.(1) Several mutants showed defects at their spindle poles and were hence named after the magnetic poles of the earth or geo-magnetic phenomena associated with them, like Polo and Aurora. Currently, the conserved family of Plks consists of many members throughout various species. Multiple Plks are present in mammalian cells (Plk1, Plk2/Snk, Plk3/Fnk/Prk, and Plk4/Sak) and Xenopus (Plx1-3), whereas in other species only one member has been identified, like Polo in Drosophila, Cdc5 in budding yeast and Plo1 in fission yeast. Plks are now viewed as important regulators of multiple functions before and during the mitotic cell division. In this review, we will focus our attention on human Plk1 and its family members Plk2-4 and the many roles they play during mitosis. Furthermore, we will describe the currently knowledge of the regulation of these functions.

Citations

Nov 26, 2013·Journal of Molecular Modeling·Balu KamarajRituraj Purohit
Aug 3, 2011·Molecules and Cells·Ravichandran N MuruganJeong Kyu Bang
Aug 9, 2011·Nature Cell Biology·David F KashatusChristopher M Counter
Feb 2, 2011·Nature Reviews. Clinical Oncology·Edina Komlodi-PasztorTito Fojo
Jul 31, 2010·Nature Reviews. Drug Discovery·Klaus Strebhardt
Dec 22, 2007·Nature Reviews. Molecular Cell Biology·Iain M Cheeseman, Arshad Desai
Mar 24, 2009·Nature Reviews. Molecular Cell Biology·Vincent Archambault, David M Glover
Jul 15, 2009·Nature Structural & Molecular Biology·Sang-Moon YunKyung S Lee
Jul 31, 2013·Nature Structural & Molecular Biology·Jun XuJunmin Quan
Feb 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Begoña García-AlvarezGuillermo Montoya
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mark E BurkardPrasad V Jallepalli
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Takumi MatsumotoPaul M Hwang
Apr 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jung-Eun ParkKyung S Lee
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yoshikazu JohmuraKyung S Lee
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hongyu SunFrances E Jensen
Apr 2, 2011·The Journal of Biological Chemistry·Young H KangKyung S Lee
Dec 4, 2009·Molecular Biology of the Cell·Lori Jo WilmethCharles Bradley Shuster
Aug 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ashley D SawleAndrew R Cossins
Mar 11, 2008·Eukaryotic Cell·Hui LiArturo De Lozanne
Sep 17, 2008·Molecular and Cellular Biology·Lin-Yu LuJunjie Chen
Jan 20, 2011·Molecular and Cellular Biology·Guillermo de CárcerMarcos Malumbres
Feb 4, 2009·Molecular and Cellular Biology·Thierry J HornerPerry J Blackshear
Jun 1, 2012·Biochemistry Research International·Magdalena J Koziol, John B Gurdon
Jan 24, 2009·Cell Division·Lin-Yu Lu, Xiaochun Yu
May 25, 2010·Nonlinear Biomedical Physics·Abdul-Wali Ms Ajlouni, Hussam A Al-Rabai'ah
Sep 3, 2011·Journal of Clinical Bioinformatics·Eri KawataTaira Maekawa
Feb 8, 2008·Genome Biology·Vincent Archambault, David M Glover
Apr 9, 2009·Journal of Cell Science·Chang-Young JangGuowei Fang

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