Poloxamer 407-induced atherogenesis in the C57BL/6 mouse

Atherosclerosis
W K PalmerT P Johnston

Abstract

Poloxamer 407 (P-407) induces hyperlipidemia in the rat. It was the purpose of this investigation to determine if chronic P-407 administration would produce atherogenic arterial lesions in the C57BL/6 mouse, a strain reported to be susceptible to hyperlipidemia-induced atherosclerotic plaque formation. One injection (i.p.) of P-407 (0.5g/kg) produced hypercholesterolemia in the mouse that peaked at 24 h and returned to control levels by 96 h following treatment. Four groups of mice were maintained: (1) saline injected (C); (2) P-407-injected (0.5g/kg every 3rd day) (P); (3) P-407 injected plus cholic acid in the diet (PC); and (4) mice fed a high cholesterol (CHOL) diet containing cholic acid (HF). Mice from each group were sacrificed following 90, 145, 200, or 300 days of treatment. Plasma lipid concentrations, hepatic CHOL concentrations (145 and 300 day), and aortic atherogenic lesion areas were measured. Plasma CHOL and triglyceride remained at control levels throughout the 300 days in the C group. CHOL of the HF animals plateaued at approximately 225 mg/dl. P-407 produced CHOL concentrations of 600 mg/dl in P mice and 1000-1500 mg/dl in PC animals. There was no lesion formation in C mice. However, by 90 days lesions were p...Continue Reading

References

Apr 1, 1990·Journal of Nutritional Science and Vitaminology·H OdaA Yoshida
Feb 20, 1989·Biochimica Et Biophysica Acta·T Chajek-ShaulY Stein
Sep 1, 1988·Trends in Pharmacological Sciences·J Shepherd, C J Packard
Dec 1, 1987·Atherosclerosis·B PaigenR A Williams
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·J A García-SáinzV E Valles
Sep 14, 1993·Biochemical Pharmacology·T P Johnston, W K Palmer
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·Y NakashimaR Ross
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R L ReddickN Maeda
May 3, 1996·Science·J L Breslow
May 1, 1997·Journal of Cardiovascular Pharmacology·T P Johnston, W K Palmer

❮ Previous
Next ❯

Citations

Nov 11, 2006·Pharmaceutical Research·Gilles DumortierJean Claude Chaumeil
Oct 15, 2010·Archives of Pharmacal Research·Jaepyoung ChoEuichaul Oh
Jan 22, 2003·Advanced Drug Delivery Reviews·Alexander V KabanovDonald W Miller
Sep 1, 2000·International Journal of Pharmaceutics·E Ruel-GariépyJ Leroux
Oct 18, 2001·International Journal of Pharmaceutics·T P JohnstonS Shefer
Mar 20, 2008·The Journal of Biological Chemistry·Nuttaporn WongsirirojWilliam S Blaner
Jul 7, 2005·Tissue Engineering·Sarwat F KhattakSusan C Roberts
Dec 22, 1999·Journal of Cardiovascular Pharmacology·T P JohnstonW K Palmer
Sep 2, 2008·Canadian Journal of Physiology and Pharmacology·Thomas P Johnston, David J Waxman
Jun 24, 2011·Journal of Pharmaceutical Sciences·Dalia A Hamdy, Dion R Brocks
Apr 9, 2013·Clinical Oral Implants Research·Henning SchliephakeGerhard Iglhaut
Dec 17, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mohammed F ShamjiLori A Setton
May 24, 2008·The Journal of Pharmacy and Pharmacology·Thomas P Johnston, David J Waxman
Apr 5, 2012·The Journal of Pharmacy and Pharmacology·Tomoyuki YasudaTatsuro Ishida
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eve Ruel-Gariépy, Jean-Christophe Leroux
Apr 21, 2016·Journal of Pharmacological Sciences·Jinhee ParkDae-Hyun Hahm
Feb 7, 2006·Atherosclerosis·Victoria C CoggerDavid G Le Couteur
Jul 2, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T A KorolenkoE Machova
Jun 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Islam HamadS Moein Moghimi
May 10, 2001·Rapid Communications in Mass Spectrometry : RCM·Z TakátsL Hegedüs
May 16, 2009·Expert Opinion on Therapeutic Patents·Xiao-Jie JuLiang-Yin Chu
Jul 5, 2005·Journal of Lipid Research·John S MillarJeffrey T Billheimer
Apr 17, 2018·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Unji LeeHee Eun Kang
Aug 5, 2017·Journal of Cardiovascular Pharmacology·Thomas P JohnstonAmirhossein Sahebkar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.