Poloxamer-hydroxyethyl cellulose-α-cyclodextrin supramolecular gels for sustained release of griseofulvin

International Journal of Pharmaceutics
Xelhua MarcosCarmen Alvarez-Lorenzo

Abstract

Supramolecular gels of poloxamer-hydroxyethyl cellulose (HEC)-α-cyclodextrin (αCD) were developed aiming to obtain synergisms regarding solubilization and sustained release of griseofulvin for topical application. The effects of αCD concentration (0-10%w/w) on the phase behavior of aqueous dispersions of Pluronic(®) P123 (14%w/w) mixed with HEC (2%w/w) were evaluated at 4, 20 and 37°C. The cooperative effects of the inclusion complex formation between poly(ethylene oxide) (PEO) blocks and HEC with αCD prevented phase separation and led to supramolecular networks that solubilize the antifungal drug. Rheological and bioadhesive properties of gels with and without griseofulvin could be easily tuned modulating the polymers proportions. Supramolecular gels underwent sol-gel transition at lower temperature than P123 solely dispersions and enabled drug sustained release for at least three weeks. All gels demonstrated good biocompatibility in the HET-CAM test. Furthermore, the drug-loaded gels showed activity against Trichophyton rubrum and Trichophyton mentagrophytes and thus may be useful for the treatment of tinea capitis and other cutaneous fungal infections.

References

Nov 1, 1972·Journal of Biomedical Materials Research·I R Schmolka
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexander V KabanovValery Yu Alakhov
Feb 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carmen Alvarez-LorenzoValerij Ya Grinberg
Dec 2, 2005·Pharmaceutical Research·Carmen Rodriguez-TenreiroJuan J Torres-Labandeira
Feb 24, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Maria KarlbergSylvaine Ragout
Jul 4, 2006·Pharmacology & Therapeutics·Nobuhiro Nishiyama, Kazunori Kataoka
Nov 25, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Carmen Alvarez-LorenzoAngel Concheiro
Apr 9, 2008·Biomacromolecules·Véronique WintgensCatherine Amiel
Mar 24, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Christophe TraveletGeorges Hadziioannou
Jun 15, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Uttam KedarVilasrao Kadam
Jul 6, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Geneviève GaucherJean-Christophe Leroux
Dec 21, 2013·Current Topics in Medicinal Chemistry·Susana M N SimõesCarmen Alvarez-Lorenzo
Dec 3, 2014·International Journal of Pharmaceutics·Maria Campaña-SeoaneFrancisco J Otero-Espinar
Jan 20, 2015·Biotechnology Advances·Alejandro Sosnik, Maya Menaker Raskin
Feb 14, 2015·Chemical Communications : Chem Comm·Susana M N SimõesCarmen Alvarez-Lorenzo
Feb 18, 2015·International Journal of Biological Macromolecules·Mohammad Reza Saboktakin, Roya Mahdavi Tabatabaei
Sep 13, 2015·International Journal of Pharmaceutics·C Del RosarioA Delgado

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Citations

Jun 28, 2016·Journal of Pharmaceutical Sciences·Iurii Antoniuk, Catherine Amiel
Mar 9, 2018·International Journal of Molecular Sciences·Ana Rey-Rico, Magali Cucchiarini
May 18, 2019·Nanomaterials·Blanca Lorenzo-VeigaCarmen Alvarez-Lorenzo
Dec 28, 2019·Pharmaceutics·Natallia DubashynskayaYury A Skorik
Feb 19, 2020·Expert Opinion on Drug Delivery·Hani AbdeltawabManisha Sharma
Jul 22, 2018·Frontiers in Chemistry·Tânia F CovaArtur J M Valente
Jan 8, 2020·Materials·Adrian DomińskiPiotr Kurcok
Jan 25, 2019·Gels·Ty Christoff-TempestaJulia H Ortony
May 16, 2021·International Journal of Pharmaceutics·Blanca Lorenzo-VeigaHakon Hrafn Sigurdsson
Jul 31, 2016·Carbohydrate Polymers·Mirna Pereira MoreiraIara F Gimenez

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