Poly (caprolactone) microparticles and chitosan thermogels based injectable formulation of etoricoxib for the potential treatment of osteoarthritis

Materials Science & Engineering. C, Materials for Biological Applications
P ArunkumarR Srivastava

Abstract

This study aimed to evaluate Poly (caprolactone) microparticles (MPs) loaded composite injectable Chitosan gel (CICGs) as a dual purpose (visco-supplement and intra articular drug delivery depot) therapeutic agent for the treatment of Osteoarthritis. Etoricoxib (COX-2 inhibitor), a highly hydrophobic drug was chosen as a model drug for the study. When administered orally, Etoricoxib poses severe cardiovascular toxicity issues. So, we have attempted to deliver this drug intra-articularly, which could retain the drug longer in the joint region and thus could ameliorate these toxicity issues. CICGs were prepared by dispersing MPs in the chitosan-Ammonium hydrogen phosphate solution and incubated at 37 °C. Rheology studies proved that gels were stable and had visco-elastic properties comparable to that of existing visco-supplements. The in vitro drug release profiles of CICGs were found to be more controlled when compared to MPs and bare chitosan gel (BCGs). In vitro and in vivo biocompatibility studies proved that the gels were biocompatible. In vivo synovial drug clearance studies proved that CICGs had a better drug retention capacity than BCGs and MPs. In vivo fluorescence imaging results confirmed that CICGs could stay longer i...Continue Reading

References

Jan 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K H Jones, J A Senft
Apr 23, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lutz BräutigamGerd Geisslinger
Oct 22, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jong-Cheol JeongKilwon Cho
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eve Ruel-Gariépy, Jean-Christophe Leroux
Jan 25, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·N V S RamakrishnaM Koteshwara
Aug 9, 2005·Seminars in Arthritis and Rheumatism·Piercarlo Sarzi-PuttiniBianca Canesi
Apr 1, 2006·Advanced Drug Delivery Reviews·Nicole GerwinAndrea Lucke
Apr 25, 2006·Advanced Drug Delivery Reviews·Steven Abramson
Jun 3, 2006·European Journal of Pharmacology·Qing ChenLi-Ping Sun
Jan 8, 2008·Seminars in Arthritis and Rheumatism·Loren LaineMarc Hochberg
Feb 29, 2008·Journal of Pharmaceutical Sciences·Claus LarsenPia H Andersen
Sep 13, 2008·International Journal of Pharmaceutics·Yu Tang, Jagdish Singh
Dec 6, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Arthur OkumuRaimar Löbenberg
Jun 30, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Nicole M Martin, Michael H Picard
Dec 25, 2010·International Journal of Biological Macromolecules·R JayakumarS V Nair
May 15, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·D Hernán Pérez de la OssaA I Torres Suárez
Jun 5, 2012·Journal of Materials Science. Materials in Medicine·Shaun W McLaughlinLakshmi S Nair
Sep 13, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhi-peng ChenJinhuo Pan
Jan 17, 2013·Biomaterials·Patricia L FoleyCato T Laurencin
Jul 1, 2012·Carbohydrate Polymers·Riccardo A A MuzzarelliAntonio Gigante
May 8, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jennifer R Weiser, W Mark Saltzman
May 27, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Stephanie SupperThierry Vandamme
Sep 15, 2014·Acta Biomaterialia·Laura KyllönenDavid Eglin
May 2, 2015·Biomacromolecules·Nathan P BirchJessica D Schiffman

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Citations

Mar 16, 2017·Drug Delivery and Translational Research·Amir H SoleimaniAfsaneh Lavasanifar
Dec 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kewen LeiJiandong Ding
May 23, 2018·Journal of Tissue Engineering·Khandmaa DashnyamHae-Won Kim
Apr 14, 2021·Journal of Pharmaceutical Sciences·Mariam ZewailNabila Boraie
Nov 4, 2017·International Journal of Biological Macromolecules·Mukesh DhankaRohit Srivastava
Dec 11, 2017·International Journal of Biological Macromolecules·Mukesh DhankaRohit Srivastava
Sep 14, 2021·Drug Delivery·Liwei MaoJun Zou

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