Poly-epsilon-caprolactone nanoparticles enhance ursolic acid in vivo efficacy against Trypanosoma cruzi infection

Materials Science & Engineering. C, Materials for Biological Applications
Juliana Palma AbriataJuliana Maldonado Marchetti

Abstract

Despite affecting millions of people worldwide, Chagas disease is still neglected by the academia and industry and the therapeutic option available, benznidazole, presents limited efficacy and side effects. Within this context, ursolic acid may serve as an option for treatment, however has low bioavailability, which can be enhanced through the encapsulation in polymeric nanoparticles. Therefore, herein we developed ursolic acid-loaded nanoparticles with poly-ε-caprolactone by the nanoprecipitation method and characterized them for particle size, zeta potential, polydispersity, encapsulation efficiency, morphology by scanning electron microscopy and thermal behavior by differential scanning calorimetry. Results indicated that an appropriate ratio of organic phase/aqueous phase and polymer/drug is necessary to produce smaller particles, with low polydispersity, negative zeta potential and high drug encapsulation efficiency. In vitro studies indicated the safety of the formulation against fibroblast culture and its efficacy in killing T. cruzi. Very importantly, the in vivo study revealed that the ursolic acid-loaded nanoparticle is as potent as the benznidazole group to control parasitemia, which could be attributed to improved b...Continue Reading

Citations

May 28, 2019·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Greta VolpedoSteve Oghumu
May 10, 2020·Drug Delivery and Translational Research·Kedar PrayagAnil B Jindal
Dec 29, 2020·Carbohydrate Polymers·Antônia Carla de Jesus OliveiraMônica Felts de La Roca Soares
Dec 17, 2020·Antibiotics·Vanessa Raquel GreattiRosemeire Cristina Linhari Rodrigues Pietro
Apr 10, 2021·Journal of Experimental Pharmacology·Ana Lia MazzetiVanessa Carla Furtado Mosqueira
Jun 19, 2021·Frontiers in Molecular Biosciences·Satabdi Datta Choudhury

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