Abstract
The study was to develop poly-γ-glutamic acid (γ-PGA)-coated Doxorubicin (Dox) lipoplexes that enhance the antitumor activity against liver tumors. γ-PGA-coated lipoplexes were performed by electrostatistically attracting to the surface of cationic charge liposomes with anionic γ-PGA. With the increasing of γ-PGA concentration, the particle size of γ-PGA-coated Dox lipoplexes slightly increased, the zeta potential from positive shifted to negative, and the entrapment efficiency (EE) were no significant change. The release rate of γ-PGA-coated Dox lipoplexes slightly increased at acidic pH, the accelerated Dox release might be attributed to greater drug delivery to tumor cells, resulting in a higher antitumor activity. Especially, γ-PGA-coated Dox lipoplexes exhibited higher cellular uptake, significant in vitro cytotoxicity in HepG2 cells, and improved in vivo antitumor efficacy toward HepG2 hepatoma-xenografted nude models in comparison with Dox liposomes and free Dox solution. In addition, the analysis results via flow cytometry showed that γ-PGA-coated Dox lipoplexes induce S phase cell cycle arrest and significantly increased apoptosis rate of HepG2 cells. In conclusion, the presence of γ-PGA on the surface of Dox lipoplexe...Continue Reading
References
Jun 21, 2002·Journal of Drug Targeting·Yoshinobu TakakuraMitsuru Hashida
Oct 28, 2004·Gastroenterology·F Xavier BoschRamon Cléries
Dec 16, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dmitry VolodkinVincent Ball
Jun 24, 2008·Critical Reviews in Biotechnology·Bhavik Manocha, Argyrios Margaritis
Jun 27, 2008·Annals of Surgery·Itaru EndoWilliam R Jarnagin
Jul 24, 2008·British Journal of Cancer·T LammersG Storm
Feb 24, 2009·Biomaterials·Tomoaki KurosakiHitoshi Sasaki
Mar 17, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amr S Abu LilaHiroshi Kiwada
Nov 26, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tomoaki KurosakiHitoshi Sasaki
Jun 11, 2010·Chemistry & Biology·Yves PommierChristophe Marchand
Jul 1, 2010·BMC Cancer·Lesley A SmithAlison Jones
Aug 4, 2010·International Journal of Pharmaceutics·Cuifeng WangChuanbin Wu
Sep 25, 2010·Biomaterials·Jing YaoXiaojing Sun
Jun 28, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Lisa M KaminskasChristopher J H Porter
Dec 16, 2011·Biomaterials·Chuangnian ZhangZhi Yuan
Feb 22, 2012·International Journal of Pharmaceutics·Na QiYu Zhang
Dec 19, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jianxun DingXuesi Chen
Apr 19, 2013·Journal of Drug Targeting·Yoshiyuki HattoriYoshie Maitani
Jun 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jianxun DingXuesi Chen
Jul 9, 2013·Acta Biomaterialia·Di LiXuesi Chen
Jan 28, 2014·International Journal of Pharmaceutics·Ji-Eon KimDae-Duk Kim
Jan 1, 2014·Results in Pharma Sciences·Yoshiyuki HattoriEtsuo Yonemochi
Sep 1, 2015·Acta Biomaterialia·Kexin HuangXuesi Chen
Mar 4, 2017·Theranostics·Bo ShiXuesi Chen
Jun 7, 2013·Biomaterials Science·Jianxun DingXuesi Chen
Citations
Jun 6, 2018·Drug Delivery·He-Lin XuYing-Zheng Zhao
Apr 8, 2020·Future Oncology·Sayantani RoychoudhuryNilesh Kumar Sharma
Sep 24, 2020·Biomaterials Science·Fangying YuFuqiang Hu
Feb 2, 2020·Nanoscale Research Letters·Hua Qin YinGang Ye
Jun 5, 2020·Drug Design, Development and Therapy·Na QiAimin Li
Dec 3, 2020·Pharmaceutics·Moon Sup YoonDae Hwan Shin