Poly I:C induces Mx transcription and promotes an antiviral state against sole aquabirnavirus in the flatfish Senegalese sole (Solea senegalensis Kaup)

Fish & Shellfish Immunology
A Fernandez-TrujilloM Manchado

Abstract

Mx is an interferon-induced protein that protects against viral infections. In this study the absolute number of Mx transcripts after poly I:C injection (a synthetic dsRNA) or sole aquabirnavirus (solevirus) inoculation in Senegalese sole (Solea senegalensis Kaup) has been quantified. Mx expression profiles differed clearly in both experimental conditions; the induction response was faster and more intense after poly I:C injection than after solevirus inoculation. Moreover, pre-injection of soles with poly I:C prior to solevirus infection eliminated the induction of Mx expression associated with this virus. To evaluate the possible interference of poly I:C treatments on solevirus replication, the mRNA levels of the virus capsid protein (VP2) were determined by RT-PCR. VP2 transcripts were hardly detected in poly I:C pre-injected animals from 12 to 72 h after solevirus inoculation. All these data suggest that poly I:C is able to induce an antiviral state that interferes with solevirus replication, and support the suitability of Mx expression analysis as a marker to study the defensive response against solevirus.

References

Sep 1, 1986·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·W Ahne, I Thomsen
Apr 1, 1983·Canadian Journal of Microbiology·P Dobos, T E Roberts
May 1, 1995·The Journal of General Virology·P FrostK E Christie
Aug 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G D Trobridge, J A Leong
Jun 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M Degré
Dec 16, 1997·Developmental and Comparative Immunology·B RobertsenJ A Leong
Jan 23, 1999·Immunological Reviews·J C LeongB Simon
Aug 24, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·V Jensen, B Robertsen
Sep 20, 2000·Fish & Shellfish Immunology·R NygaardB Robertsen
Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Georg KochsOtto Haller
Apr 5, 2002·Genome Research·Jae-Hong KoTomomasa Watanabe
May 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·K WOLFE PYLE
Dec 17, 2003·Fish & Shellfish Immunology·C TafallaB Novoa
May 5, 2004·Fish & Shellfish Immunology·Karen P Plant, Ronald L Thune
Nov 18, 2004·Immunological Reviews·Sidney PestkaMark R Walter
Mar 9, 2005·Fish & Shellfish Immunology·E AbolloB Novoa
Jun 14, 2005·Fish & Shellfish Immunology·Bergljót Magnadóttir
Jun 13, 2006·Fish & Shellfish Immunology·M Alejandra Fernández-TrujilloJulia Béjar
Jun 16, 2007·Biochimie·Otto HallerGeorg Kochs

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Citations

Mar 31, 2010·Marine Biotechnology·Bergljot Magnadottir
Mar 12, 2016·Veterinary Immunology and Immunopathology·J A González-MariscalJ Béjar
Mar 9, 2013·Fish & Shellfish Immunology·S PicchiettiA M Fausto
Jan 9, 2016·Veterinary Research·Daniel Alvarez-TorresEsther Garcia-Rosado
Aug 10, 2010·Journal of Virological Methods·Ching-An PengWei-Lun Wang
Jun 9, 2015·Fish & Shellfish Immunology·Kittipong ThanasaksiriHidehiro Kondo
Jul 23, 2013·Fish & Shellfish Immunology·Bei HuangP Nie
Jun 16, 2016·Frontiers in Physiology·Patricia PereiroBeatriz Novoa
Mar 17, 2018·Viruses·Timothy J Green, Peter Speck

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