Poly-L-ornithine/fucoidan-coated calcium carbonate microparticles by layer-by-layer self-assembly technique for cancer theranostics

Journal of Materials Science. Materials in Medicine
Pei WangShibin Wang

Abstract

Recently, the layer-by-layer (LbL) self-assembly technology has attracted the enormous interest of researchers in synthesizing various pharmaceutical dosage forms. Herewith, we designed a biocompatible drug delivery system containing the calcium carbonate microparticles (CaCO3 MPs) that coated with the alternatively charged polyelectrolytes, i.e., poly-L-ornithine (PLO)/fucoidan by LbL self-assembly process (LbL MPs). Upon coating with the polyelectrolytes, the mean particle size of MPs obtained from SEM observations increased from 1.91 to 2.03 μm, and the surface of LbL MPs was smoothened compared to naked CaCO3 MPs. In addition, the reversible zeta potential changes have confirmed the accomplishment of layer upon a layer assembly. To evaluate the efficiency of cancer therapeutics, we loaded doxorubicin (Dox) in the LbL MPs, which resulted in high (69.7%) drug encapsulation efficiency. The controlled release of Dox resulted in the significant antiproliferative efficiency in breast cancer cell line (MCF-7 cells), demonstrating the potential of applying this innovative drug delivery system in the biomedical field.

References

Jun 1, 1997·Transplantation Proceedings·R CalafioreP Brunetti
Feb 24, 2001·The Journal of Pharmacy and Pharmacology·K A FosterK L Audus
Sep 14, 2004·Biomacromolecules·Dmitry V VolodkinGleb B Sukhorukov
Jun 16, 2005·Biomaterials·Marcus D DarrabieEmmanuel C Opara
Nov 5, 2008·Journal of the American Chemical Society·Wei WeiZhe-Yu Shen
Aug 17, 2012·Molecular Pharmaceutics·Dong ZhaoSi-Xue Cheng
Oct 30, 2012·Colloids and Surfaces. B, Biointerfaces·Ping LiangSi-Xue Cheng
Aug 6, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Chao DuShaokui Cao
Jan 31, 2014·Marine Drugs·Jong-Young Kwak
Jul 20, 2014·Carbohydrate Polymers·Meng-Xia ChenDai-Yin Peng
Oct 16, 2014·Colloids and Surfaces. B, Biointerfaces·Jin-Long WuSi-Xue Cheng
Dec 3, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carolin GanasWolfgang J Parak
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Rizwan WahabAbdulaziz A Al-Khedhairy
Feb 6, 2017·Biological & Pharmaceutical Bulletin·Yusuke KamiyaHideshi Natsume
Nov 12, 2017·Acta Biomaterialia·Marina Martínez-CarmonaMaría Vallet-Regí

❮ Previous
Next ❯

Citations

Aug 8, 2019·Marine Drugs·Aleksandra CitkowskaKatarzyna Winnicka
Mar 22, 2020·Marine Drugs·Ahmed Zayed, Roland Ulber
Jan 12, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Albert R MuslimovAlexander S Timin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Cancer Cell Invasion: Nanomedicine

Nanomedicine is a promising alternative for cancer detection and therapy that utilizes nanoparticles, such as liposomes. Nanoparticles can potentially target cancer cell invasion and metastasis. Discover the latest research on Cancer Cell Invasion: Nanomedicine here.