Poly (lactide-co-glycolide) nanoparticles containing coumarin-6 for suppository delivery: in vitro release profile and in vivo tissue distribution

Drug Delivery
J G EleyJ McLane

Abstract

A delivery system consisting of the lipophilic fluorescent dye coumarin-6 embedded into polymer nanoparticles in a suppository base was formulated. Particle diameters of 400-1100 nm were produced by a salting-out method and measured by laser diffraction. Nanoparticles reach the systemic circulation via fenestrated capillaries or remain within rectal membranes to release their contents. Dissolution over 168 hr was initially rapid followed by a steady decline, and tissue distribution showed coumarin-6 to be present in liver and lungs for a similar time period while in kidney, small intestines, and blood up to 96 hr. Microscopic observations showed nanoparticles to be present in blood up to 72 hr.

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Citations

Jun 8, 2012·Molecular Pharmaceutics·Emilie RogerJayanth Panyam
Apr 8, 2010·Science Translational Medicine·James P BertramErin B Lavik
Nov 30, 2011·Journal of Nanobiotechnology·Anil Mahapatro, Dinesh K Singh
Apr 22, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Owen I Corrigan, Xue Li
Sep 25, 2015·Pharmaceutical Development and Technology·Jayanant Iemsam-ArngSatita Tapaneeyakorn
May 13, 2006·Journal of Biomaterials Science. Polymer Edition·Carlos E Astete, Cristina M Sabliov
May 3, 2005·Nature Reviews. Drug Discovery·Howard Rosen, Thierry Abribat
Apr 25, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Amit K GoyalGoutam Rath
Mar 3, 2020·Frontiers in Bioengineering and Biotechnology·Divesha EssaViness Pillay

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