Poly methacrylic acid-alginate semi-IPN microparticles for oral delivery of insulin: a preliminary investigation

Journal of Biomaterials Applications
S Sajeesh, Chandra P Sharma

Abstract

Microparticles of Poly methacrylic acid (P1) and novel semi-interpenetrating network composed of Poly methacrylic acid-alginate (P2) were prepared and their application in oral insulin delivery was evaluated. The microparticles were characterized by scanning electron microscopy (SEM) for morphological studies. Insulin loading onto the microparticles was performed by the diffusion filling method and insulin encapsulated microparticles were subjected to in vitro release study in buffer solution of pH 1.2 and 7.4. The release kinetics at pH 7.4 exhibited sustained release of insulin for more than 5 h in case of PMAA microparticles whereas burst release of insulin (90% of total insulin loaded) within 1 h of study was observed in the case of PMAA-alginate microparticles. At pH 1.2, around 30% of insulin loaded was released from both microparticles within 2 h of study.

References

Jan 1, 1995·Journal of Biomaterials Science. Polymer Edition·R Narayani, K P Rao
Jan 1, 1995·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·M S BeenaC P Sharma
Nov 1, 1995·Journal of Pharmaceutical Sciences·J P BaiJ H Guo
Jun 6, 2000·Advanced Drug Delivery Reviews·S Wee, W R Gombotz
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·D AmeyeJ P Remon
Apr 12, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Madeline Torres-LugoNicholas A Peppas
May 7, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mariko MorishitaNicholas A Peppas
Feb 1, 2003·Journal of Biomaterials Applications·Sunita Prem Victor, Chandra P Sharma
Jul 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·V R Sinha, Aman Trehan
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·M G Cascone, S Maltinti

❮ Previous
Next ❯

Citations

Dec 16, 2005·AAPS PharmSciTech·Deepti JainDipak K Majumdar
Oct 9, 2007·Journal of Pharmaceutical Sciences·Rajesh SinghJames W Lillard
Jun 17, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nicholas A Peppas, Nikhil J Kavimandan
Jan 31, 2006·Journal of Biomaterials Applications·Deepti JainA K Panda
Feb 6, 2007·Journal of Biomaterials Science. Polymer Edition·Shih-Jer HuangJenn-Shing Chen
Apr 1, 2005·Journal of Microencapsulation
Jan 25, 2019·Gels·Víctor H Pérez-Luna, Orfil González-Reynoso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.