Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system

Journal of Controlled Release : Official Journal of the Controlled Release Society
Hyeonjeong JeonWon Jong Kim

Abstract

This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, β-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between β-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems.

References

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Citations

Jun 22, 2016·Expert Opinion on Drug Delivery·Stefan Lorscheidt, Alf Lamprecht
Oct 28, 2016·Journal of Materials Science. Materials in Medicine·Paulo Emilio FeuserPedro H Hermes de Araújo
Feb 7, 2017·Chemistry : a European Journal·Tina SkorjancAli Trabolsi
Nov 30, 2018·Expert Opinion on Drug Delivery·Thomas VangijzegemSophie Laurent
Feb 1, 2020·Recent Patents on Anti-cancer Drug Discovery·Hongyu TaoXiukun Lin
Aug 22, 2017·Advanced Functional Materials·Haoyuan Huang, Jonathan F Lovell
Feb 23, 2019·Materials·Joanna Dulińska-LitewkaAnna Karewicz
Jan 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yasemin YarHavva Yagci Acar
Jun 24, 2020·Scientific Reports·Asahi TomitakaMadhavan Nair
May 23, 2020·Drug Delivery and Translational Research·Ana Cláudia SantosFrancisco Veiga
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Katarzyna ReczyńskaWojciech Chrzanowski
Jul 2, 2020·Advanced Drug Delivery Reviews·David C LutherVincent M Rotello
Jan 21, 2021·Biomedical Materials·Qin ZhangWeimin Li
Jul 20, 2020·Anti-cancer Agents in Medicinal Chemistry·Shiyu ChenRunliang Feng
Nov 5, 2020·Carbohydrate Polymers·Bingren TianJiayue Liu

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