Poly-ubiquitin profile in Alzheimer disease brain

Neurobiology of Disease
Antonella TramutolaD Allan Butterfield

Abstract

Alzheimer disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory, reasoning and other cognitive functions. Pathologically, patients with AD are characterized by deposition of senile plaques (SPs), formed by β-amyloid (Aβ), and neurofibrillary tangles (NTFs) that consist of aggregated hyperphosphorylated tau protein. The accumulation of insoluble protein aggregates in AD brain can be associated with an impairment of degradative systems. This current study investigated if the disturbance of protein polyubiquitination is associated with AD neurodegeneration. By using a novel proteomic approach, we found that 13 brain proteins are increasingly polyubiquitinated in AD human brain compared to age-matched controls. Moreover, the majority of the identified proteins were previously found to be oxidized in our prior proteomics, and these proteins are mainly involved in protein quality control and glucose metabolism. This is the first study showing alteration of the poly-ubiquitin profile in AD brain compared with healthy controls. Understanding the onset of the altered ubiquitin profile in AD brain may contribute to identification of key molecular regulators of cognitive decline. In AD, deficits of the p...Continue Reading

Citations

Nov 12, 2019·Expert Review of Proteomics·Fabio Di DomenicoAntonella Tramutola
Oct 28, 2019·Current Alzheimer Research·Anuruddhika Udayangani RathnayakeHee-Guk Byun
Apr 8, 2020·Chemistry : a European Journal·Paula OrtegaSara de Pablo
Jan 25, 2019·Current Medicinal Chemistry·Weslley Felix de OliveiraMaria Tereza Dos Santos Correia
Jun 6, 2020·Frontiers in Cell and Developmental Biology·Long WangTae Ho Lee
Mar 21, 2020·Frontiers in Cell and Developmental Biology·Dongmei ChenTae Ho Lee
Nov 10, 2018·Translational Neurodegeneration·Antonella TramutolaFabio Di Domenico
Feb 14, 2020·International Journal of Molecular Sciences·Shannon E DoughertyGustavo M Silva
Oct 13, 2020·Journal of Alzheimer's Disease : JAD·Zhenting HuangZhiyou Cai
Nov 20, 2020·Cell Death and Differentiation·François Le Guerroué, Richard J Youle
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lujain Bader EddinShreesh Ojha
Jan 12, 2022·Metabolic Brain Disease·Lalit SharmaDeepak Kumar

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