PMID: 12753763May 20, 2003Paper

Poly(acrylic acid) microgels (carbopol 934)/surfactant interactions in aqueous media. Part I: nonionic surfactants

International Journal of Pharmaceutics
R Barreiro-IglesiasA Concheiro

Abstract

The interaction between Tween 80 and Pluronic F-127 with carbopol in water was studied as a function of surfactant concentration. 0.25% carbopol microgels dispersions showed a continuous decrease in transmittance, viscosity and conductivity when surfactant concentration ranged from 0.01-0.02% to 0.50% Tween 80 or from 0.03-0.06% to 0.30% Pluronic F-127. These limit values can be considered as the critical association concentration and the saturation binding concentration, respectively. In this concentration range, a strong rise in pH (from 3.18 to 3.50) suggested that surfactant-polymer binding occurred mainly through a stoichiometric hydrogen-bonding interaction between the oxyethylene and carboxylic groups. In the presence of carbopol, the concentration of Tween 80 at the air/water interface decreases as the surfactant is adsorbed onto the polymer and drawn into the bulk solution. In contrast, the interaction with the polymer seems to change the conformation of the expanded chains of Pluronic F-127, making it easier for more molecules of surfactant to be at the interface and increasing the thickness of the interfacial surfactant layer. Fluorescence probes indicated that the carbopol network presents a more apolar medium than ...Continue Reading

References

Dec 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H R Lin, K C Sung
Nov 2, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·R Barreiro-IglesiasA Concheiro

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Citations

Dec 4, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rafael Barreiro-IglesiasAngel Concheiro
May 20, 2003·International Journal of Pharmaceutics·R Barreiro-IglesiasA Concheiro
Feb 27, 2013·Biofouling·Maria José Garcia-FernandezCarmen Alvarez-Lorenzo
Nov 1, 2006·Journal of Pharmaceutical Sciences·Pornpen Werawatganone, Dale Eric Wurster
Oct 19, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S M N SimõesC Alvarez-Lorenzo
Feb 20, 2016·ACS Applied Materials & Interfaces·Daniel M Schenck, Jennifer Fiegel
Oct 31, 2006·International Journal of Pharmaceutics·J M LlabotD A Allemandi
Apr 29, 2005·Journal of Pharmaceutical Sciences·Danny K ChouMark Cornell Manning
Apr 3, 2013·Carbohydrate Polymers·Carolina Siqueira Franco Picone, Rosiane Lopes Cunha
Mar 22, 2014·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mohamed Abbas Ibrahim, Mahmoud El-Badry
Mar 31, 2005·Carbohydrate Research·Dian-Shu YinYing-Jin Yuan
Jan 22, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Thórunn O ThorgeirsdóttirBo Nyström
Jun 13, 2006·International Journal of Pharmaceutics·Pornpen WerawatganoneAmaraporn Roopdee
Sep 20, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yixuan DongXiaoming Xu
Feb 8, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·C DiabC Tribet
Oct 18, 2020·Journal of Colloid and Interface Science·Barbara V FariasSaad A Khan

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