Poly(ADP-ribose)--a unique natural polymer structural features, biological role and approaches to the chemical synthesis

Nucleosides, Nucleotides & Nucleic Acids
Mikhail S Drenichev, Sergey N Mikhailov

Abstract

Poly(ADP-ribose) (PAR) is a natural polymer, taking part in numerous important cellular processes. Several enzymes are involved in biosynthesis and degradation of PAR. One of them, poly(ADP-ribose)polymerase-1 (PARP-1) is considered to be a perspective target for the design of new drugs, affecting PAR metabolism. The structure of PAR was established by enzymatic hydrolysis and further analysis of the products, but total chemical synthesis of PAR hasn't been described yet. Several approaches have been developed on the way to chemical synthesis of this unique biopolymer.

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Citations

Jun 20, 2016·Bioorganic & Medicinal Chemistry Letters·Mikhail S Drenichev, Sergey N Mikhailov
Feb 23, 2020·Biochemistry. Biokhimii︠a︡·D K NilovV K Švedas
Dec 19, 2018·Biochemical Society Transactions·Mikhail V MakarovMarie E Migaud
Apr 5, 2020·International Journal of Molecular Sciences·Dmitry NilovVasily M Studitsky
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexandra L ZakharenkoSergey N Mikhailov
Mar 2, 2021·Chemical Research in Toxicology·Nadin WedlerAndrea Hartwig

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Methods Mentioned

BETA
NMR
X-ray
deacylation
glycosylation

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