Poly(ADP-ribose) mediates asymmetric division of mouse oocyte

Cell Research
Bingteng XieJie Qiao

Abstract

Before fertilization, mammalian oocyte undergoes an asymmetric division which depends on eccentric positioning of the spindle at the oocyte cortex to form a polar body and an egg. Since the centriole is absent and, as a result, the polar array microtubules are not fully developed in oocytes, microtubules have seldom been considered as required for eccentric positioning of the spindle, while actin-related forces have instead been proposed to be primarily responsible for this process. However, the existing models are largely conflicting and the underlying mechanism of asymmetric division is still elusive. Here we show that poly(ADP-ribose) (PAR) is enriched at mouse oocyte cortical area throughout meiosis. Specific removal of cortical PAR results in an ectopic spindle and a failure of asymmetric division. During spindle migration, when the spindle deviates from the center of oocyte by a pushing force of cytoplasmic actin, the short polar array microtubules emanating from the juxtacortical spindle pole extend to the cortex and penetrate into cortical PAR, docking and stabilizing the spindle at the cortex which facilitates the asymmetric division. This process depends on the affinity between PAR and microtubule-associated proteins ...Continue Reading

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Citations

Nov 28, 2018·Journal of Cellular Physiology·Xiaoyan LiLing Gu
Feb 1, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoling LiangShangrong Fan
Feb 1, 2020·Journal of Cellular and Molecular Medicine·Hao WangShangrong Fan
Mar 14, 2020·Biology of Reproduction·Meng-Hao PanShao-Chen Sun
Apr 14, 2019·Cellular and Molecular Life Sciences : CMLS·Yimei JinMo Li
Feb 25, 2021·Nature Communications·Wenjing LiMo Li
Mar 17, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Feifei Shi, Xizeng Feng
May 22, 2021·Journal of Cellular Physiology·Lin-Lin HuShao-Chen Sun
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Yu WuMo Yang
Jan 15, 2022·Developmental Cell·Daniela Londoño-VásquezAhmed Z Balboula

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Methods Mentioned

BETA
dot blots
dot blot
PCR
immunoprecipitation
microscale thermophoresis
co-immunoprecipitation
pull down
dot-blot
electrophoresis

Software Mentioned

Imaris

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