Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy

American Journal of Physiology. Heart and Circulatory Physiology
Jyothish B PillaiMahesh P Gupta

Abstract

Poly(ADP-ribose) polymerase-1 (PARP), a chromatin-bound enzyme, is activated by cell oxidative stress. Because oxidative stress is also considered a main component of angiotensin II-mediated cell signaling, it was postulated that PARP could be a downstream target of angiotensin II-induced signaling leading to cardiac hypertrophy. To determine a role of PARP in angiotensin II-induced hypertrophy, we infused angiotensin II into wild-type (PARP(+/+)) and PARP-deficient mice. Angiotensin II infusion significantly increased heart weight-to-tibia length ratio, myocyte cross-sectional area, and interstitial fibrosis in PARP(+/+) but not in PARP(-/-) mice. To confirm these results, we analyzed the effect of angiotensin II in primary cultures of cardiomyocytes. When compared with PARP(-/-) cardiomyocytes, angiotensin II (1 microM) treatment significantly increased protein synthesis in PARP(+/+) myocytes, as measured by (3)H-leucine incorporation into total cell protein. Angiotensin II-mediated hypertrophy of myocytes was accompanied with increased poly-ADP-ribosylation of nuclear proteins and depletion of cellular NAD content. When cells were treated with cell death-inducing doses of angiotensin II (10-20 microM), robust myocyte cell de...Continue Reading

References

Jul 10, 1999·The Journal of Biological Chemistry·S Galande, T Kohwi-Shigematsu
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·P ParadisM Nemer
Sep 6, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Bürkle
Sep 11, 2002·Trends in Cell Biology·Jeffrey Smith
Oct 2, 2002·Journal of the American College of Cardiology·Jozef BartunekMarc Goethals
Nov 21, 2002·Cellular and Molecular Life Sciences : CMLS·P O Hassa, M O Hottiger
Jun 18, 2003·Cell·W Lee Kraus, John T Lis
Aug 16, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Valentina GrishkoStephen Schaffer
Dec 10, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Tzu-Hurng ChengJin-Jer Chen
Apr 7, 2004·Circulation·Norbert FreyJoseph A Hill
May 18, 2004·Genes & Development·Wei-Xing ZongCraig B Thompson
Jun 11, 2004·Annual Review of Biochemistry·Gil Blander, Leonard Guarente
Sep 18, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jyothish B PillaiMahesh P Gupta
Sep 24, 2004·The Journal of Biological Chemistry·Javier R RevolloShin-ichiro Imai
Feb 3, 2005·The Journal of Biological Chemistry·Matt KaeberleinBrian K Kennedy
May 3, 2005·Nature Reviews. Drug Discovery·Prakash Jagtap, Csaba Szabó
Jun 1, 2005·Trends in Pharmacological Sciences·Pal PacherCsaba Szabó
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Giovanna BasileElena Zocchi

❮ Previous
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Citations

Apr 30, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xiao Z ShenKenneth E Bernstein
Jan 30, 2013·Molecular Aspects of Medicine·Carles CantóPeter Bai
Feb 2, 2013·Molecular Aspects of Medicine·Nicola J Curtin, Csaba Szabo
May 31, 2011·Cardiovascular Research·Huaqing ZhuTianqing Peng
May 28, 2009·Molecular and Cellular Biology·Senthilkumar B RajamohanMahesh P Gupta
Dec 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·M SulaimanM Gupta
Jul 20, 2012·Physiological Reviews·Ruben NogueirasMatthias H Tschöp
Feb 5, 2011·Circulation Research·Pei HanChing-Pin Chang
Apr 1, 2010·Disease Models & Mechanisms·Manlio VinciguerraNadia Rosenthal
May 13, 2014·Cell and Tissue Research·Thomas NührenbergLutz Hein
Oct 2, 2014·Cell Calcium·Angel Zarain-HerzbergRafael Estrada-Avilés
Aug 13, 2009·Cellular and Molecular Life Sciences : CMLS·Rosy El RamyFrançoise Dantzer
May 4, 2010·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Chetan P HansA Hamid Boulares
Nov 26, 2008·Journal of Molecular and Cellular Cardiology·Dan HuangKai Huang
Jun 3, 2008·The International Journal of Biochemistry & Cell Biology·Michael V G LatronicoDaniele Catalucci
Aug 29, 2007·Neuroscience Letters·Perla Deyanira MaldonadoJosé Pedraza-Chaverrí
Mar 30, 2007·Congestive Heart Failure·George W Booz
Mar 12, 2008·Basic & Clinical Pharmacology & Toxicology·Paola Yam-CanulJosé Pedraza-Chaverri
Jul 3, 2013·The Journal of Pathology·Salma Awad Mahmoud, Coralie Poizat
Aug 28, 2007·Journal of Molecular and Cellular Cardiology·Mahesh P Gupta
Oct 24, 2006·Trends in Pharmacological Sciences·Csaba SzaboRaymond A Swanson
Jan 28, 2015·British Journal of Pharmacology·Xiao-Jun FengPei-Qing Liu
Dec 25, 2012·Biochemical and Biophysical Research Communications·Biao GengPeiqing Liu
Jun 4, 2011·The Biochemical Journal·Ilona GeistrikhMalka Cohen-Armon
Jan 28, 2014·Biochemical and Biophysical Research Communications·Min LiuPeiqing Liu
Dec 7, 2013·Journal of Receptor and Signal Transduction Research·Tian-Biao Zhou, Zong-Pei Jiang
May 27, 2014·Molecular and Cellular Endocrinology·Min LiuPei-Qing Liu
Aug 2, 2016·Seminars in Cell & Developmental Biology·Tina JubinRasheedunnisa Begum
Jan 13, 2017·Clinical and Experimental Pharmacology & Physiology·Ting ZhengYan-Qing Chen
Mar 16, 2017·Journal of Cellular and Molecular Medicine·Xiao-Hui GuanHong-Bo Xin
Jun 25, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Junco Shibayama WarrenJunichi Sadoshima
Sep 18, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Heiko Funke-KaiserThomas Unger

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