Polyamidoamine (Yet Not PAMAM) dendrimers as bioinspired materials for drug delivery: structure-activity relationships by molecular simulations

Biomacromolecules
Lorenzo MetullioSabrina Pricl

Abstract

In this paper, we report the results obtained from a comprehensive characterization of newly synthesized dendrimeric molecules in a solvated environment, by computer-aided simulations. The evidences allowed us to formulate some structure-activity relationships (SARs) between the experimentally verified cytotoxicity/noncytotoxicity of these compounds and some molecular features such as, for instance, radius of gyration, molecular shape, and dimensions. In particular, all noncytotoxic dendrimers were characterized by a more dense and globular shape and by a smoother surface pattern, as quantified by their fractal dimension D.

References

Jan 1, 1977·Annual Review of Biophysics and Bioengineering·F M Richards
Jun 1, 1992·Anti-cancer Drugs·R Duncan
Jan 1, 1969·International Review of Cytology·L Weiss
Aug 1, 1968·Biological Reviews of the Cambridge Philosophical Society·G M Cook
Jan 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E C WienerP C Lauterbur
Sep 1, 1993·Bioconjugate Chemistry·J Haensler, F C Szoka
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·J F Kukowska-LatalloJ R Baker
Jan 1, 1996·Journal of Biomedical Materials Research·J C RobertsR T Zera
Nov 1, 1996·Bioconjugate Chemistry·M X TangF C Szoka
Sep 28, 1999·Pharmaceutical Science & Technology Today·M Liu, J M Fréchet
Sep 30, 1999·Bioconjugate Chemistry·A U BielinskaJ R Baker
Jun 12, 2002·Bioorganic & Medicinal Chemistry·Maurizio FermegliaSabrina Pricl
Jul 23, 2002·Current Opinion in Chemical Biology·Anil K PatriJames R Baker
Dec 10, 2002·Current Opinion in Chemical Biology·Mary J Cloninger
Jan 29, 2003·International Journal of Pharmaceutics·R JevprasesphantA D'Emanuele

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Citations

Sep 13, 2013·International Journal of Pharmaceutics·Natassa PippaPanos Macheras
Jul 29, 2010·Journal of the American Chemical Society·Raghavendra KikkeriPeter H Seeberger
Apr 29, 2008·Chemical Communications : Chem Comm·Raghavendra KikkeriPeter H Seeberger
Mar 18, 2010·Chemical Communications : Chem Comm·Raghavendra KikkeriPeter H Seeberger
Mar 12, 2011·Physical Chemistry Chemical Physics : PCCP·Pu Chun Ke, Monica H Lamm
Feb 12, 2014·Journal of Molecular Modeling·Sepideh Amjad-IranaghHamid Modarress
May 13, 2014·Toxicology Letters·Tin-Tin Win-ShweSeishiro Hirano
Apr 11, 2012·International Journal of Pharmaceutics·Natassa PippaCostas Demetzos
Jun 15, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Loan HuynhChristine Allen
Dec 7, 2007·Bioorganic & Medicinal Chemistry·Mauro MazzeiRoberta Loddo
Mar 2, 2007·Polymer International·Hannah L Crampton, Eric E Simanek
Jun 15, 2012·Journal of Computational Chemistry·Vishal MaingiPrabal K Maiti
May 25, 2010·Chemistry : a European Journal·Giovanni Maria PavanSabrina Pricl
Nov 4, 2006·Advanced Drug Delivery Reviews·Sean EkinsCheng Chang
Nov 22, 2013·Physical Chemistry Chemical Physics : PCCP·Maria Francesca OttavianiSabrina Pricl
Nov 5, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Srinivas ParimiClive A Prestidge
Aug 14, 2009·Environmental Science & Technology·Jyotsnendu GiriYongchun Tang
Mar 17, 2011·Journal of the American Chemical Society·Luís C S FilipeAntónio M Baptista
Feb 13, 2007·The Journal of Physical Chemistry. B·Giulio ScocchiSabrina Pricl

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