PMID: 16646157May 2, 2006Paper

Polyamine and aminoguanidine treatments to promote structural and functional recovery in the adult mammalian brain after injury: a brief literature review and preliminary data about their combined administration

Journal of Physiology, Paris
Sarah Schimchowitsch, Jean-Christophe Cassel

Abstract

The regeneration potential of the adult mammalian central nervous system (CNS) is very modest, due to, among other factors, the presence of either a glial scar, or myelin-associated regeneration inhibitors such as Nogo-A, MAG and OMgp, which all interact with the same receptor (NgR). After a brief review of the key proteins (Rho and PKC) implicated in NgR-mediated signalling cascades, we will tackle the implications of cAMP and Arginase I in overcoming myelin growth-inhibitory influence, and then will focus on the effects of polyamines and aminoguanidine to propose (and to briefly support this proposal by our own preliminary data) that their association might be a potent way to enable functionally-relevant regeneration in the adult mammalian CNS.

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Citations

Mar 19, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhigang ZhouMarina Mata
Dec 9, 2009·Journal of Neurotrauma·Kamyar ZahediKenneth I Strauss
Feb 24, 2012·Neurochemical Research·Ana Carolina TramontinaCarlos-Alberto Gonçalves
Apr 3, 2012·Acta Biomaterialia·Qiang ZhangDavid L Kaplan
Oct 28, 2016·Journal of Biomedical Materials Research. Part a·Qiang ZhangXin Wang
Jun 27, 2013·Disability and Rehabilitation. Assistive Technology·Ryan FomiattiJeannine Millsteed

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