Polyamine and intestinal properties in adult rats

The British Journal of Nutrition
P DeloyerG Goessens

Abstract

We questioned whether polyamines coming from the diet or produced by intestinal microflora or by intracellular metabolism influence intestinal functions. Therefore, we compared pathogen-free rats and germ-free rats receiving a diet with low polyamine content and either treated or not treated with difluoromethylornithine (DFMO) and/or methylglyoxal bis (guanylhydrazone) (MGBG). Wet weight, protein content, DNA content, sucrase (EC 3.2.1.48), maltase (EC 3.2.1.20) and lactase (EC 3.2.1.23) specific activities, amounts of putrescine, spermidine and spermine were measured in the mucosa of the proximal and distal intestine. Body weight was also determined. Rats without microflora had a higher specific activity of maltase and higher amounts of spermidine and spermine but lower lactase specific activity than pathogen-free animals; the low-polyamine diet given to germ-free rats had little effect on the functional variables measured (decrease of maltase and lactase specific activities) and did not modify the amounts of polyamines. DFMO and/or MGBG administered to germ-free rats receiving a low-polyamine diet induced modifications of most of the variables studied. Body weight and wet weight of proximal and distal intestine decreased, dis...Continue Reading

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Citations

Nov 13, 2004·The Journal of Nutritional Biochemistry·B P BrodalH Osmundsen
May 29, 2000·The Proceedings of the Nutrition Society·G DandrifosseC Grandfils
Mar 4, 2009·Infection and Immunity·Jean M BowerMatthew A Mulvey
Jun 15, 2007·Critical Reviews in Clinical Laboratory Sciences·Nikolaus Seiler, Francis Raul
Sep 21, 2001·European Journal of Gastroenterology & Hepatology·P DeloyerG Dandrifosse
Oct 4, 2000·The Journal of Nutrition·N M DelzenneG Dandrifosse

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