PMID: 6410400Aug 1, 1983Paper

Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat

Proceedings of the National Academy of Sciences of the United States of America
G D LukS B Baylin

Abstract

The specific ornithine decarboxylase inhibitor alpha-difluoromethylornithine, when given to adult rats in vivo for 5 wk, resulted in a decrease in peripheral blood cell elements in normal rats and a marked suppression of marrow recovery in rats with chemotherapy-induced marrow hypoplasia. In normal rats, alpha-difluoromethylornithine resulted in a reduction of the leukocyte count to 73% of control, erythrocyte count to 61% of control, and platelet count to 24% of control. The bleeding time was increased to twice normal and 67% of the animals had epistaxis and 42% had melena. In rats treated with the S phase-specific chemotherapeutic agent 1-beta-D-arabinofuranosylcytosine, the simultaneous administration of alpha-difluoromethylornithine prevented the recovery of the bone marrow. The peripheral blood cell counts remained low--leukocyte count was 10% of control, and erythrocyte and platelet counts were 6% of control. All the animals developed epistaxis and melena and there was a 72% mortality. The administration of putrescine (4 mmol/kg, intraperitoneally, daily), the specific polyamine product of ornithine decarboxylase, reversed these hematologic effects in both normal and recovering marrow and resulted in rapid clinical improv...Continue Reading

References

Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G D LukS B Baylin
Nov 15, 1981·International Journal of Cancer. Journal International Du Cancer·M SiimesJ Jänne

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Citations

Apr 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·E Niskanen, W W Wharton
Jan 1, 1990·Pharmacology & Therapeutics·G S AhluwaliaD A Cooney
Oct 15, 1992·European Journal of Biochemistry·J FukuchiK Igarashi
May 1, 1996·Alcoholism, Clinical and Experimental Research·R F KleinA S Carlos
May 1, 1997·Alcoholism, Clinical and Experimental Research·R F Klein
Nov 15, 1988·International Journal of Cancer. Journal International Du Cancer·K NishiokaD M Ota
Aug 15, 1986·International Journal of Cancer. Journal International Du Cancer·D M OtaK Nishioka

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