Polyamine dendrimer-based MRI contrast agents for functional kidney imaging to diagnose acute renal failure

Journal of Magnetic Resonance Imaging : JMRI
Hisataka KobayashiRobert A Star

Abstract

To choose an efficacious renal functional MRI contrast agent to image early renal tubular damage. We synthesized and compared smaller polyamine dendrimer-based MRI contrast agents (<60 kD) that, unlike Gd-[DTPA], transiently accumulate in renal tubules and can be used to visualize renal structural and functional damage. Six dendrimer-based MRI contrast agents smaller than 60 kD were studied by high resolution dynamic micro-MRI and compared to Gd-[DTPA]-dimeglumine and Gadomer-17. The best agent, DAB-G2, was further tested in a mouse ischemia/reperfusion model to validate its efficacy. Despite unequal renal clearance rates, all polyamine dendrimer agents visualized the renal functional anatomy of the mice better than Gd-[DTPA]-dimeglumine and Gadomer-17. DAB-G2 was excreted most rapidly, yet was able to visualize mild renal tubular injury very early after injury. DAB-G2 was found to be the best candidate for functional kidney imaging and enabled early diagnosis of acute renal injury.

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Citations

Dec 1, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Maya DamianovichAnat Shirvan
Apr 26, 2011·Bioconjugate Chemistry·Michelle R LongmireHisataka Kobayashi
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