PMID: 8583963May 1, 1995Paper

Polyamine involvement in the cell cycle, apoptosis, and autoimmunity

Medical Hypotheses
W H Brooks

Abstract

The polyamines: putrescine, spermidine and spermine, are ubiquitous polycations which have numerous, unique interactions in eukaryotic cells. Polyamines are essential for cell growth, with the bulk of polyamine expression co-ordinated with the cell cycle. The length, charge, and charge distribution of polyamines permit them to interact with large anionic molecules such as DNA, RNA, and phospholipids. Here, a mechanism is proposed whereby cell cycle expression of polyamines at the start of S phase leads to disruption of transcription and splicing, giving priority to DNA and histone synthesis. Inappropriate initiation of this process in non-viable cells leads to apoptosis and may be an underlying cause of autoimmunity.

References

Aug 1, 1992·Immunology Today·L Fesus
Jan 1, 1992·Current Topics in Microbiology and Immunology·C Bello-Fernandez, J L Cleveland
Apr 3, 1992·Cell·G I EvanD C Hancock
Jul 27, 1992·FEBS Letters·S Sen, M D'Incalci
Aug 1, 1991·Experimental Cell Research·B BrüneS Orrenius
Jul 11, 1991·Nucleic Acids Research·M A BatzerP L Deininger
Mar 1, 1990·Arthritis and Rheumatism·W Zacharias, W J Koopman
Jan 1, 1991·Annual Review of Biochemistry·M A Osley
Dec 1, 1990·Biochemical Society Transactions·D M Morgan
Dec 11, 1990·Nucleic Acids Research·M A BatzerP L Deininger
Jan 1, 1989·Archives of Dermatological Research·N MizunoS Morisawa
Oct 20, 1989·Science·A R Rahmouni, R D Wells
Mar 25, 1989·Nucleic Acids Research·L M Eisenberg, O A Jänne
Feb 15, 1987·The Biochemical Journal·L Alhonen-HongistoJ Jänne
Mar 1, 1986·The Biochemical Journal·A E Pegg
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T Kohwi-ShigematsuY Kohwi
Aug 5, 1987·Journal of Molecular Biology·M M Garner, G Felsenfeld
Jan 1, 1984·Annual Review of Biochemistry·C W Tabor, H Tabor
Oct 25, 1982·Nucleic Acids Research·R MaleK Kleppe
Jan 1, 1984·Annual Review of Biochemistry·A RichA H Wang
Dec 1, 1983·Journal of Biomolecular Structure & Dynamics·D B Haniford, D E Pulleyblank
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L J Peck, J C Wang
Feb 1, 1994·Molecular and Cellular Biology·S MaheswaranG E Sonenshein
Feb 1, 1993·British Journal of Cancer·A H Wyllie

❮ Previous
Next ❯

Citations

Dec 31, 1997·Journal of Neuroimmunology·R IentileG Piedimonte
Dec 12, 2001·Bioorganic & Medicinal Chemistry Letters·Gerard F GraminskiMark R Burns
Apr 7, 2010·Biochemistry·Elena E GrintsevichAndras Muhlrad
Jun 20, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·R I ErnestusN Klug
Dec 5, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·A BouchereauF Larher
Mar 18, 2011·Biophysical Chemistry·Andras MuhlradEmil Reisler
Jul 9, 2004·Journal of the Neurological Sciences·Titti EkegrenHåkan Askmark
Mar 11, 2000·American Journal of Physiology. Cell Physiology·R M RayL R Johnson
Jan 18, 2020·Metabolomics : Official Journal of the Metabolomic Society·Yu Ra LeeBong Chul Chung
Mar 11, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·P H Hoet, B Nemery
Jul 11, 2000·Seminars in Cancer Biology·R G SchipperA A Verhofstad
Jun 11, 2002·Archives of Biochemistry and Biophysics·Laura BianchiMaria Alfonsina Desiderio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis