PMID: 3760865Nov 1, 1986Paper

Polyamine localization and biosynthesis in chemically fractionated rat retina

Journal of Neurochemistry
R IentileS Macaione

Abstract

For elucidation of polyamine localization and biosynthesis in various cell types of rat retina, the putrescine, spermidine, and spermine contents as well as the ornithine decarboxylase and S-adenosylmethionine decarboxylase activities have been measured in retinal cell layers obtained by the selective cytotoxic action of iodoacetate on photoreceptor cells and of monosodium glutamate on higher-order retinal neurons. A notable depletion only in spermine content was associated with loss of the visual cell layer. Total ornithine decarboxylase and S-adenosylmethionine decarboxylase activities per retina were significantly lower in all chemically fractionated tissue, but loss of the photoreceptor layer produced the greatest decrease. The specific activities of these enzymes did not show marked changes in rat retinas deprived of inner neurons. The data support the suggestions that polyamine synthesis, storage, and catabolism have different distributions in the retinal layers and that the spermine levels and the high value of the spermine/spermidine molar ratio might depend essentially on the proportion of rods to cones.

References

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Apr 1, 1973·Journal of Neurochemistry·G G Shaw, A J Pateman
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Jan 1, 1985·Neurochemistry International·R IentileR M Di Giorgio

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Citations

Jul 1, 1988·Brain Research Bulletin·M MüllerA Dorn
Aug 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G TaibiG Tesoriere
Nov 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G TaibiC Nicotra
Sep 21, 2015·Amino Acids·Miranda Burnette, Jeremiah J Zartman
Aug 17, 2021·Frontiers in Cellular Neuroscience·Alejandro VilaJohn O'Brien

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