Polyamine-mediated control of mammalian S-adenosyl-L-methionine decarboxylase expression: effects on the content and translational efficiency of the mRNA

Biochemical and Biophysical Research Communications
L PerssonO Heby

Abstract

The expression of mammalian AdoMet decarboxylase, a key enzyme in polyamine synthesis, was shown to be regulated by polyamines at two different levels. Polyamine depletion of Ehrlich ascites tumor cells induced a marked compensatory increase in the synthesis of the enzyme, as measured by 35S-methionine pulse-labeling and immuno-precipitation. This increase in synthesis rate was counteracted by provision of spermidine, which reduced the synthesis of AdoMet decarboxylase to an undetectable level. Northern analysis revealed a nearly 2-fold increase in the amount of AdoMet decarboxylase mRNA when the putrescine and spermidine content was depleted. This increase in AdoMet decarboxylase mRNA content cannot account for the more than 5-fold increase in synthesis rate, indicating a feedback regulation also at the level of mRNA translation.

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Citations

Mar 9, 1993·Biochemical Pharmacology·L Stjernborg, L Persson
Jan 1, 1990·Life Sciences·J A López-BallesterR Peñafiel
Dec 1, 1992·Pharmacology & Therapeutics·A E Pegg, P P McCann
Apr 1, 1990·Trends in Biochemical Sciences·O Heby, L Persson
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·L M Shantz, A E Pegg
Dec 1, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gunnar Houen
Apr 30, 1992·Biochemical and Biophysical Research Communications·A SuorsaA Pajunen

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