Polyamine oxidase 5 loss-of-function mutations in Arabidopsis thaliana trigger metabolic and transcriptional reprogramming and promote salt stress tolerance

Plant, Cell & Environment
Xavier ZarzaRubén Alcázar

Abstract

The family of polyamine oxidases (PAO) in Arabidopsis (AtPAO1-5) mediates polyamine (PA) back-conversion, which reverses the PA biosynthetic pathway from spermine and its structural isomer thermospermine (tSpm) into spermidine and then putrescine. Here, we have studied the involvement of PA back-conversion in Arabidopsis salinity tolerance. AtPAO5 is the Arabidopsis PAO gene member most transcriptionally induced by salt stress. Two independent loss-of-function mutants (atpao5-2 and atpao5-3) were found to exhibit constitutively higher tSpm levels, with associated increased salt tolerance. Using global transcriptional and metabolomic analyses, the underlying mechanisms were studied. Stimulation of abscisic acid and jasmonate (JA) biosynthesis and accumulation of important compatible solutes, such as sugars, polyols and proline, as well as TCA cycle intermediates were observed in atpao5 mutants under salt stress. Expression analyses indicate that tSpm modulates the transcript levels of several target genes, including many involved in the biosynthesis and signalling of JA, some of which are already known to promote salinity tolerance. Transcriptional modulation by tSpm is isomer-dependent, thus demonstrating the specificity of thi...Continue Reading

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Citations

Nov 22, 2016·International Journal of Molecular Sciences·He TianGuanghou Shui
Feb 27, 2017·Plant, Cell & Environment·Laura De Gara, Christine H Foyer
May 5, 2017·Journal of Experimental Botany·Jayakumar BoseStephen D Tyerman
Jul 2, 2019·The Plant Journal : for Cell and Molecular Biology·Shiori ShinoharaTaku Takahashi
Sep 19, 2019·Plant Signaling & Behavior·Aditi TailorSatish C Bhatla
Sep 5, 2019·Plants·Konstantinos PaschalidisJi-Hong Liu
Apr 23, 2020·Plants·Taku Takahashi
May 28, 2019·Frontiers in Plant Science·Wei WangJi-Hong Liu
Nov 4, 2020·Cells·Rubén AlcázarAntonio F Tiburcio
Feb 13, 2021·Plant Signaling & Behavior·Changxin Liu, Rubén Alcázar
Jan 31, 2021·Plants·Aigerim SoltabayevaSudhakar Srivastava

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