PMID: 2497556May 15, 1989Paper

Polyamine synthesis in rat lungs injured with alpha-naphthylthiourea

Toxicology
J W OlsonM N Gillespie

Abstract

The diamine, putrescine, and polyamines, spermidine and spermine, are low molecular weight organic cations with documented regulatory roles in cell growth and differentiation. Multiple lines of direct and indirect evidence suggest that these organic cations also may function in stimulus-response coupling processes regulating cellular injury and repair. For example, recent studies in monocrotaline-treated rats, hyperoxic rats, and in cultured pulmonary endothelial cells suggest that polyamines regulate pulmonary endothelial integrity and may thus participate in development and/or regression of acute edematous lung injury. To determine if the polyamines are involved in a well-characterized animal model of acute lung injury, the present experiments assessed the relation between changes in polyamine synthesis and development of edema in lungs from rats treated with alpha-naphthylthiourea (ANTU). ANTU caused dose- and time-dependent increases in the lung activity of the initial and rate-limiting enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC) and in the lung contents of the polyamines putrescine, spermidine, and spermine. ANTU also caused dose- and time-dependent increases in the lung wet-to-dry weight ratio indicati...Continue Reading

References

Nov 1, 1987·The Journal of Clinical Investigation·H KoenigC Y Lu
Nov 15, 1983·Biochemical and Biophysical Research Communications·H KoenigC Y Lu
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H KoenigC Y Lu
Jun 15, 1983·Biochemical and Biophysical Research Communications·A D HackerT K O'Brien
Sep 1, 1982·Archives of Biochemistry and Biophysics·H Pösö, A E Pegg

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Citations

Mar 16, 1990·Toxicology·M A Hollinger, S N Giri

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