PMID: 7091579Jan 1, 1982Paper

Polyamines and globin binding in sickle cell disease

The American Journal of Pediatric Hematology/oncology
C L NattaL T Kremzner

Abstract

Erythrocytes obtained from patients with sickle cell anemia contain five to ten times more spermine than controls. The preferential binding of beta s globin to red cell stroma may be mediated by spermine and may account in part for the membrane abnormalities found in sickle cell disorders.

Related Concepts

Hemoglobin AA
Anemia, Sickle Cell
Erythrocytes
Hemoglobin A
Hemoglobin SS
Polyamines
Plasma Protein Binding Capacity
Spermine

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