Polyamines are essential in embryo implantation: expression and function of polyamine-related genes in mouse uterus during peri-implantation period

Endocrinology
Yue-Chao ZhaoZeng-Ming Yang

Abstract

Polyamines are key regulators in cell growth and differentiation. It has been shown that ornithine decarboxylase (Odc) was essential for post-implantation embryo development, and overexpression of spermidine/spermine N1-acetyltransferase will lead to ovarian hypofunction and hypoplastic uteri. However, the expression and function of polyamine-related genes in mouse uterus during early pregnancy are still unknown. In this study we investigated the expression, regulation, and function of polyamine-related genes in mouse uterus during the peri-implantation period. Odc expression was strongly detected at implantation sites and stimulated by estrogen treatment. The expression of Odc antizyme 1 and spermidine/spermine N1-acetyltransferase was also highly shown at implantation sites and regulated by Odc or polyamine level in uterine cells. Embryo implantation was significantly inhibited by alpha-difluoromethylornithine, an Odc inhibitor. Moreover, the reduction of Odc activity caused by alpha-difluoromethylornithine treatment was compensated by the up-regulation of S-adenosylmethionine decarboxylase gene expression. Collectively, our results indicated that the coordinated expression of uterine polyamine-related genes may be important ...Continue Reading

References

Oct 15, 1990·Biochemical Pharmacology·V G BruntonH M Wallace
Jan 1, 1987·Cancer Chemotherapy and Pharmacology·J C RomijnT A Splinter
Jun 17, 1999·FEBS Letters·C StefanelliC M Caldarera
Sep 5, 2001·Molecular and Cellular Biology·H PendevilleJ L Cleveland
Sep 19, 2003·The Biochemical Journal·Heather M WallaceAlun Hughes
Mar 11, 2004·European Journal of Biochemistry·Juhani JänneTuomo A Keinänen
Jun 8, 2004·Endocrine Reviews·S K DeyHaibin Wang
Oct 29, 2004·Nature Reviews. Cancer·Eugene W Gerner, Frank L Meyskens
Oct 30, 2004·Endocrinology·Carmen M BastidaRafael Peñafiel
Apr 2, 2005·Biological & Pharmaceutical Bulletin·Masaki KobayashiKeijiro Samejima
Oct 6, 2005·Journal of Cellular and Molecular Medicine·Nikolaus Seiler, Francis Raul
Feb 7, 2006·The Journal of Biological Chemistry·Anthony E Pegg
Feb 18, 2006·Nature Reviews. Genetics·Haibin Wang, Sudhansu K Dey

❮ Previous
Next ❯

Citations

Aug 27, 2010·Archives of Oral Biology·Kamil K HozyaszPawel P Jagodzinski
Feb 28, 2013·Reproductive Biology and Endocrinology : RB&E·Jonathan M GreenePeter L Ryan
Dec 21, 2005·Acta Veterinaria Hungarica·S Gy FeketeZs Szendro
Oct 20, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Xiangfang ZengShiyan Qiao
Jan 23, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Stephen R FrankenbergMarilyn B Renfree
Jul 16, 2009·IUBMB Life·Anthony E Pegg
Jun 27, 2015·Molecular and Cellular Endocrinology·Dang-Dang LiZhan-Peng Yue
Mar 25, 2014·Molecular Reproduction and Development·Roney dos Santos RamosMario Binelli
Mar 21, 2017·General and Comparative Endocrinology·Joseph R D FernandesArnab Banerjee
Feb 8, 2018·Journal of Animal Science and Biotechnology·Yasser Y LenisFuller W Bazer
Jul 28, 2011·Endocrine Reviews·Pavine L C LefèvreBruce D Murphy
Nov 13, 2018·Reproduction, Fertility, and Development·Jane C Fenelon, Bruce D Murphy
Oct 4, 2019·Molecular Reproduction and Development· AnuradhaAmitabh Krishna
Jan 14, 2020·Zygote : the Biology of Gametes and Early Embryos·Nasser GhanemDawit Tesfaye
Feb 10, 2011·Endocrinology·Pavine L C LefèvreBruce D Murphy
Feb 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Pavine L C LefèvreBruce D Murphy
Mar 23, 2017·Amino Acids·Bo KangZhixin Yi
Feb 10, 2017·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Zi-Long LiZeng-Ming Yang
Jun 24, 2017·Biology of Reproduction·Jane C Fenelon, Bruce D Murphy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.