Polyamines as clinical laboratory tools

Clinica Chimica Acta; International Journal of Clinical Chemistry
A Gugliucci


Since their discovery by Antoni van Leeuwenhoek in 1678 until the recent development of transgenic mice expressing proteins altering polyamine levels in a tissue-specific manner, polyamines have been the object of intense research efforts which have shed light on several biological and pathological processes. From the discovery of a particular form of proteasome regulation of the catabolism of the key regulatory enzyme in their synthetic pathway, to the experimental cancer treatment or prevention with polyamine antagonists or inhibitors of the latter enzyme, a whole spectrum of interests can be revealed. Still, many aspects of their functions remain elusive and difficulties inherent in their analysis, which relies on sophisticated high-performance liquid chromatographic (HPLC) methods, and the lack of standardization; have hampered the transit from the research realm to the standard clinical laboratory domain. Their assay in biological fluids has been used for cancer diagnosis and for monitoring anticancer treatment. In this article, we attempt to provide an overview of polyamine structure, nutritional value, metabolism, and physiological roles. Next, we will summarize the main analytical methods on which we count, and finally ...Continue Reading


Apr 6, 1978·Biochimica Et Biophysica Acta·J JänneA Raina
Nov 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·K D CooperO M Rennert
Nov 1, 1975·The Biochemical Journal·N Seiler, B Eichentopf
Sep 30, 1992·International Journal of Cancer. Journal International Du Cancer·H S GarewalB Fennerty
May 1, 1991·Journal of Cellular Biochemistry·B G FeuersteinL J Marton
Aug 1, 1991·Annals of Medicine·J JänneP Leinonen
Feb 1, 1990·The Biochemical Journal·E CocuzziS I Chung
Jan 1, 1990·Digestion·N Seiler
Jan 1, 1990·Experimental Gerontology·P R Holt, G D Luk
Nov 30, 1989·Biochemical and Biophysical Research Communications·P CelanoR A Casero
Dec 8, 1989·Biochimica Et Biophysica Acta·P Elworthy, E Hitchcock
Jan 1, 1989·Acta neurochirurgica·C von EssenE Hitchcock
Oct 1, 1987·Canadian Journal of Physiology and Pharmacology·N Seiler
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B G FeuersteinL J Marton
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S C FeinsteinPhilip Coffino
Jan 1, 1985·The Biochemical Journal·N SeilerB Knödgen
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·D H Russell
Aug 1, 1984·Mechanisms of Ageing and Development·G Scalabrino, M E Ferioli
Dec 15, 1994·Biochemical and Biophysical Research Communications·Y WakabayashiH Takahashi
Nov 22, 1994·Biochemistry·A L OstermanM A Phillips
May 17, 1997·Biochimica Et Biophysica Acta·V Catros-QuemenerJ Chapman
May 23, 1998·The International Journal of Biochemistry & Cell Biology·A Tabib, U Bachrach
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·H C HaR A Casero
Dec 10, 1999·The Biochemical Journal·K Igarashi, K Kashiwagi
May 18, 2000·Biochemical and Biophysical Research Communications·K Igarashi, K Kashiwagi
Aug 18, 2000·Free Radical Biology & Medicine·J W Baynes, S R Thorpe
Jan 4, 2001·Stroke; a Journal of Cerebral Circulation·T ElsM Hennerici
Jan 4, 2001·The Journal of Dermatology·D R Bickers, M Athar
Feb 13, 2001·Kidney International. Supplement·F GalliU Buoncristiani
Mar 10, 2001·The British Journal of Nutrition·C Löser
Mar 29, 2001·Diabetologia·R SinghL Beilin
Oct 9, 2001·The Journal of Biological Chemistry·L M PfefferL R Johnson
Jan 31, 2002·Journal of Chromatography. B, Biomedical Sciences and Applications·M Y Khuhawar, G A Qureshi
Feb 21, 2002·Biochemical Pharmacology·Georg T WondrakMyron K Jacobson
Mar 22, 2002·Journal of Internal Medicine·H Vlassara, M R Palace
Apr 30, 2002·Diabetes·Manuel Portero-OtínAnne Nègre-Salvayre
Jun 13, 2002·Neuroreport·Josep DotJosé Rodríguez-Alvarez
Feb 8, 2003·The Journal of Biological Chemistry·Ramesh M RayLeonard R Johnson
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Thoralf WendtAnn Marie Schmidt
Jul 29, 2003·Diabetes·Roya Babaei-JadidiPaul J Thornalley
Jan 1, 1926·The Biochemical Journal·H W DudleyW W Starling


Mar 5, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gary Gang ChenGustavo Turecki
Apr 18, 2007·Antimicrobial Agents and Chemotherapy·Dong-Hyeon Kwon, Chung-Dar Lu
Apr 28, 2006·Antimicrobial Agents and Chemotherapy·Dong H Kwon, Chung-Dar Lu
Apr 23, 2005·Infection and Immunity·Ana F GarciaJ F Alderete
Feb 13, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anne R SimoneauFrank L Meyskens
Jan 1, 2009·Journal of Basic and Clinical Physiology and Pharmacology·G BjelakovicJ Basic
Sep 2, 2011·The Protein Journal·S Zahra BathaieS Zahra Moosavi-Nejad
May 16, 2009·Scandinavian Journal of Gastroenterology·Hai-Tao JinIsto Nordback
Jan 15, 2015·Biosensors·Adam J Gilbertsen, Bryan J Williams
Sep 11, 2014·Nutrition and Cancer·Ashley J VargasPatricia A Thompson
Jan 10, 2008·Journal of Separation Science·Katarzyna DziarkowskaPiotr P Wieczorek
Nov 23, 2006·Nutrition·Elvira LarquéSalvador Zamora
May 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elbaleeq A GubartallahBahruddin Saad
Mar 31, 2018·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·María Dolores Jiménez-MartínezAna Belén Bautista-Ortín
Sep 30, 2009·Chemical Communications : Chem Comm·Oksana Danylyuk, Kinga Suwinska
Nov 13, 2018·Reproduction, Fertility, and Development·Jane C Fenelon, Bruce D Murphy
Mar 29, 2014·Basic & Clinical Pharmacology & Toxicology·Mario GrossiBengt-Olof Nilsson
Jun 18, 2019·Journal of Food Science and Technology·Mônica Bartira da SilvaGiuseppina Pace Pereira Lima

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Chemistry, Clinical
Malignant Neoplasms
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