Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis.

American Journal of Physiology. Cell Physiology
Tongtong ZouJian-Ying Wang

Abstract

Polyamines regulate multiple signaling pathways and are implicated in many aspects of cellular functions, but the exact molecular processes governed by polyamines remain largely unknown. In response to environmental stress, repression of translation is associated with the assembly of stress granules (SGs) that contain a fraction of arrested mRNAs and are thought to function as mRNA storage. Here we show that polyamines modulate the assembly of SGs in normal intestinal epithelial cells (IECs) and that induced SGs following polyamine depletion are implicated in the protection of IECs against apoptosis. Increasing the levels of cellular polyamines by ectopic overexpression of the ornithine decarboxylase gene decreased cytoplasmic levels of SG-signature constituent proteins eukaryotic initiation factor 3b and T-cell intracellular antigen-1 (TIA-1)-related protein and repressed the assembly of SGs induced by exposure to arsenite-induced oxidative stress. In contrast, depletion of cellular polyamines by inhibiting ornithine decarboxylase with α-difluoromethylornithine increased cytoplasmic eukaryotic initiation factor 3b and TIA-1 related protein abundance and enhanced arsenite-induced SG assembly. Polyamine-deficient cells also exhi...Continue Reading

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Citations

Jun 28, 2013·Nucleic Acids Research·Ran ZhuangJian-Ying Wang
Apr 5, 2013·Wiley Interdisciplinary Reviews. RNA·Richard E Lloyd
Aug 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Enna Dogra GuptaManchikatla Venkat Rajam
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Oct 5, 2021·Frontiers in Cell and Developmental Biology·Mohammad Reza AsadiMaryam Rezazadeh

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis