Polyarteritis nodosa-induced pancreaticoduodenal artery aneurysmal rupture

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
Steven LevinNedaa Skeik

Abstract

Polyarteritis nodosa (PAN) is a systemic, necrotizing vasculitis of small- and medium-sized arteries typically with multiorgan involvement. Most cases of PAN are idiopathic, although hepatitis B or C virus infections and hairy cell leukemia are important in the pathogenesis of some cases. PAN is characterized as segmental transmural inflammation of muscular arteries. Diagnosis is based on clinical suspicion, a negative immunofluorescence test for antineutrophil cytoplasmic antibodies, and whenever possible, biopsy conformation. Angiographic images may reveal microaneurysms affecting the renal, hepatic, or mesenteric vasculature. Aneurysmal formation and rupture are important complications that can be fatal. Treatment may warrant immunosuppression with steroids and cyclophosphamide. If left untreated, PAN can be fatal. To our knowledge, we report the second documented case of PAN-induced ruptured inferior pancreaticoduodenal artery aneurysm.

Citations

Jun 9, 2016·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hiroyuki SatoTasuku Nagasawa

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