PMID: 2491640Jan 1, 1989Paper

Polyarthritis in MRL-lpr/lpr mice: mouse type II collagen is antigenic but not arthritogenic

Autoimmunity
M C BoissierC Fournier

Abstract

In addition to a lupus-like syndrome and massive T cell proliferation, MRL-lpr/lpr(MRL/l) mice develop an arthritic process very similar serologically and histologically to human rheumatoid arthritis (RA). Recently, we have developed in DBA/1 mice an experimental model of autoimmune arthritis (EAA) which shares clinical features with RA, by injecting homologous type II collagen (CII). In order to investigate the possible relationship between the spontaneous polyarthritis of MRL/l mice and collagen induced EAA, we immunized MRL/l mice with mouse (M) CII. Our findings revealed that the injection of 100 micrograms M-CII in young or old MRL/l mice did not modify the articular pathology which spontaneously develops in non-injected mice. Circulating autoantibodies to native M-CII were found in the sera of immunized young mice but were not detected in non injected or immunized old mice. Conversely, denatured alpha 1 (II) chains or CB peptides derived from M-CII were recognized by most of the MRL/l sera whether mice had been immunized or not. The incidence of positive sera as well as the intensity of the response evaluated by Western blot analysis increased with the age of the mice. Taken together, our data suggest that, even if the in...Continue Reading

References

Oct 1, 1979·Arthritis and Rheumatism·R A EisenbergF J Dixon
Jan 1, 1978·The Journal of Clinical Investigation·D E TrenthamJ R David
Sep 1, 1977·The Journal of Experimental Medicine·D E TrenthamA H Kang
Dec 1, 1986·European Journal of Immunology·C FournierM Michel-Béchet
Oct 1, 1987·Clinical Immunology and Immunopathology·S GayW J Koopman
Jun 1, 1986·Annals of the Rheumatic Diseases·J C EdwardsD A Willoughby
Jan 1, 1987·Arthritis and Rheumatism·A TarkowskiL Klareskog
Jan 1, 1985·Rheumatology International·A Pataki, C Rordorf-Adam
Jan 1, 1981·Immunological Reviews·A N Theofilopoulos, F J Dixon
Mar 1, 1982·The Journal of Clinical Investigation·J M StuartA H Kang
Feb 1, 1982·Scandinavian Journal of Immunology·J T Hom, N Talal
Mar 1, 1984·Arthritis and Rheumatism·K PhadkeR S Baker
Jun 1, 1982·The Journal of Experimental Medicine·L HangF J Dixon

❮ Previous
Next ❯

Citations

May 1, 1995·European Journal of Immunology·M C BoissierC Fournier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.