Polyarthritis in primary Sjögren's syndrome represents a distinct subset with less pronounced B cell proliferation a Dutch cohort with long-term follow-up

Clinical Rheumatology
E J ter Borg, J C Kelder

Abstract

The primary goal was to investigate the differences in patients with and without polyarthritis (PA) in primary Sjögren's syndrome (pSS) in a clinical-based (real-life) setting, with respect to demographic characteristics, cumulative prevalence of other extra-glandular manifestations (EGM), hypergammaglobulinaemia and serological profile. The secondary goal was to describe the characteristics of polyarthritis in our pSS cohort. Patients diagnosed with pSS and polyarthritis but without rheumatoid arthritis (RA)-like changes on X-rays were followed up prospectively from June 1991 until August 2014, with at least one check-up each year. Patients fulfilling the criteria for concomitant connective tissue disorders were excluded. Data were collected with respect to the prevalence of systemic auto-antibodies (anti-nuclear antibodies (ANA), anti-Sjögren's syndrome-related antigen A (anti-SSA), anti-Sjögren's syndrome type B (anti-SSB) and immunoglobulin M-rheumatoid factor (IgM-RF)) and other EGM related to pSS. A total of 134 patients were included for the final analysis. The median follow-up was 86 months (range 0-368 months). Twenty-two patients (16.4 %) had polyarthritis. The prevalence of systemic auto-antibodies including rheumato...Continue Reading

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Citations

Feb 21, 2018·Biomarkers in Medicine·Chiara BaldiniStefano Bombardieri
Oct 3, 2018·Scandinavian Journal of Rheumatology·N Molano-GonzálezG Hernández-Molina
Jul 23, 2016·Immunologic Research·Andreas V Goules, Athanasios G Tzioufas
Jan 23, 2021·Expert Review of Clinical Immunology·Loukas ChatzisAndreas V Goules
Jun 25, 2021·Frontiers in Medicine·Claudio VitaliNicoletta Del Papa

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