Abstract
Polyhexamethylenebiguanide hydrochloride (PHMB), a low molecular weight polymer related to chlorohexidine (CHX), is a well-known antibacterial agent. In this study, polylactide (PLA) nanofibers loaded with PHMB were produced by electrospinning to obtain 3D biodegradable scaffolds with antibacterial properties. PLA fibers loaded with CHX were used as control. The electrospun fibers were studied and analyzed by SEM, FTIR, DSC and contact angle measurements. PHMB and CHX release from loaded scaffolds was evaluated, as well as their antibacterial activity and biocompatibility. The results showed that the nanofibers became smoother and their diameter smaller with increasing the amount of loaded PHMB. This feature led to an increase of both surface roughness and hydrophobicity of the scaffold. PHMB release was highly dependent on the hydrophilicity of the medium and differed from that determined for CHX. Lastly, PHMB-loaded PLA scaffolds showed antibacterial properties since they inhibited adhesion and bacterial growth, and exhibited biocompatible characteristics for the adhesion and proliferation of both fibroblast and epithelial cell lines.
References
Jun 14, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Richard S BlackburnStephen J Russell
Aug 9, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Meital Zilberman, Jonathan J Elsner
Sep 16, 2009·Expert Review of Medical Devices·Krasimir VasilevHans J Griesser
Sep 21, 2010·Skin Pharmacology and Physiology·B Roth, F H H Brill
Sep 21, 2010·Skin Pharmacology and Physiology·K Kaehn
Citations
Aug 27, 2015·Journal of Pharmaceutical Sciences·Joshua Boateng, Ovidio Catanzano
Nov 26, 2016·Biomaterials Science·Dong LuoGleb B Sukhorukov
Apr 6, 2019·Macromolecular Bioscience·Linlin MaXiaoming Tao
Mar 7, 2019·Royal Society Open Science·Wen ShenGuodong Fan
Jul 25, 2019·Macromolecular Bioscience·Alexander DartPeter Kingshott
Nov 28, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Melanie HornschuhGerald Müller
Jul 15, 2017·Biofabrication·Songtao GaoZhenfeng Duan
Feb 18, 2017·Biomedical Materials·M C Fernández-CalderónC Pérez-Giraldo
Jul 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhiyong QianHaifeng Liu
Sep 2, 2020·Advances in Wound Care·Wei HeSiming Yang
Oct 5, 2016·BioMed Research International·Afra HadjizadehAbdellah Ajji
Aug 5, 2017·Materials·Weiguang WangPaulo Bártolo
May 28, 2019·Polymers·Anna WorsleyLiam Good
May 12, 2018·Environmental Science and Pollution Research International·Hassan AslaniMohammad Khazaei
Jan 16, 2020·Materials·Ahui LiangMingzhong Li
Oct 17, 2019·International Journal of Molecular Sciences·Manuel RivasJordi Puiggalí
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Dan YanYao Fu
Dec 3, 2020·Frontiers in Bioengineering and Biotechnology·Haofeng QiuDongmei Huang
Mar 23, 2021·Current Tissue Microenvironment Reports·Grant Scull, Ashley C Brown
Apr 4, 2021·International Journal of Molecular Sciences·Reza ZeinaliJordi Puiggalí
Apr 29, 2021·Journal of Biomaterials Applications·Micael MontemezzoRosmary Nichele Brandalise
Jul 25, 2021·Polymers·Ruifang ZhaoLin Tan
Sep 4, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sripriya RamasamyRagunathan Manikavali Gurunadhan
Sep 8, 2021·ACS Biomaterials Science & Engineering·IJsbrand M VermueCaroline Cheng