Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs): A six-year temporal trend in Northern California pregnant women

Chemosphere
Emily ParryTracey J Woodruff

Abstract

Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants. Technical mixtures PentaBDE and OctaBDE were phased out in 2004 through voluntary and regulatory actions with DecaBDE remaining in limited use until 2013. Biomonitoring studies have shown widespread presence of PBDEs in the US and worldwide population. While some studies suggest that human serum concentrations are declining over time, it is unclear whether this trend will continue. Our objective was to examine temporal trends of PentaBDEs and their hydroxylated metabolites (OH-PBDEs) between 2008 and 2014 in populations of ethnically diverse, pregnant women residing in Northern California (n = 111). Serum samples were collected and analyzed by high resolution mass spectrometry for five PentaBDE congeners and two OH-PBDEs. We found widespread exposures in participants from all three time points (2008/09, 2011/12, 2014). Temporal patterns varied substantially by congener. BDE-47, -99 and the OH-PBDEs decreased between 2008/09-2011/12 but plateaued between 2011/12-2014. In contrast, BDE-100 decreased across all years, BDE-153 decreased in the latter years, and BDE-28 decreased initially and then increased. These findings indicate that while policies to remove ...Continue Reading

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Citations

Dec 19, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Han Yan, Barbara F Hales
May 28, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·David K ScovilleJulia Yue Cui
Feb 19, 2020·Journal of Exposure Science & Environmental Epidemiology·Jessie P BuckleyUNKNOWN program collaborators for ECHO
Aug 8, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nicole C DezielYawei Zhang
Nov 2, 2018·Environmental Research·Giehae ChoiMelissa M Smarr
Jan 8, 2021·Current Epidemiology Reports·Ann M VuongAimin Chen
Feb 10, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marília Cristina Oliveira SouzaFernando Barbosa
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Mar 27, 2021·Environment International·Kathryn M RodgersRobin E Dodson
Jul 15, 2021·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists’ Committee on Obstetric Practice

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