Polybutylcyanoacrylate nanocarriers as promising targeted drug delivery systems

Journal of Drug Targeting
Shiya GaoYanyu Xiao

Abstract

Among the materials for preparing the polymeric nanocarriers, poly(n-butylcyanoacrylate) (PBCA), a polymer with medium length alkyl side chain, is of lower toxicity and proper degradation time. Therefore, PBCA has recently been regarded as a kind of widely used, biocompatible, biodegradable, low-toxic drug carrier. This review highlights the use of PBCA-based nanocarriers (PBCA-NCs) as targeting drug delivery systems and presents the methods of preparation, the surface modification and the advantages and limitations of PBCA-NCs. The drugs loaded in PBCA-NCs are summarized according to the treatment of diseases, and the different therapeutic applications and the most recent developments of PBCA-NCs are also discussed, which provides useful guidance on the targeting research of PBCA-NCs.

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Citations

Nov 9, 2016·Acta Biomaterialia·Yoav BarkanArijit Basu
Nov 17, 2016·Journal of Biomaterials Science. Polymer Edition·Jingjing YaoWeiyun Wang
May 3, 2019·PLoS Neglected Tropical Diseases·Juliana Souza Ribeiro CostaLaura Oliveira-Nascimento
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May 29, 2021·International Journal of Pharmaceutics·Yaquelin Ramos CarrilesWolf-Dieter Mueller

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