Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs.

Molecular Pharmaceutics
Sarah A StewartEneko Larrañeta

Abstract

Implantable devices are versatile and promising drug delivery systems, and their advantages are well established. Of these advantages, long-acting drug delivery is perhaps the most valuable. Hydrophilic compounds are particularly difficult to deliver for prolonged times. This work investigates the use of poly(caprolactone) (PCL)-based implant coatings as a novel strategy to prolong the delivery of hydrophilic compounds from implantable devices that have been prepared by additive manufacturing (AM). Hollow implants were prepared from poly(lactic acid) (PLA) and poly(vinyl alcohol) (PVA) using fused filament fabrication (FFF) AM and subsequently coated in a PCL-based coating. Coatings were prepared by solution-casting mixtures of differing molecular weights of PCL and poly(ethylene glycol) (PEG). Increasing the proportion of low-molecular-weight PCL up to 60% in the formulations decreased the crystallinity by over 20%, melting temperature by over 4 °C, and water contact angle by over 40°, resulting in an increased degradation rate when compared to pure high-molecular-weight PCL. Addition of 30% PEG to the formulation increased the porosity of the formulation by over 50% when compared to an equivalent PCL-only formulation. These i...Continue Reading

References

Aug 1, 1975·Archives of Ophthalmology·K L Macoul, D Pavan-Langston
Sep 28, 1990·Science·R Langer
Oct 1, 1987·Contraception·B AffandiR S Samil
Jan 1, 1997·Advances in Experimental Medicine and Biology·T O'HaraJ Devane
Jan 27, 1999·Journal of Pharmacological and Toxicological Methods·A K Dash, G C Cudworth
Oct 31, 2000·Biomaterials·J C Middleton, A J Tipton
Apr 12, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P Costa, J M Sousa Lobo
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·Gaio ParadossiMary K Cowman
Apr 13, 2005·Drug Delivery·Sílvia Ligório Fialho, Armando da Silva Cunha
Apr 28, 2005·Contraception·Sidney FunkUNKNOWN Implanon US Study Group
Oct 4, 2005·Biomaterials·Hongfan SunPengyan Wang
Apr 7, 2007·The European Physical Journal. E, Soft Matter·R Sabater i SerraM Salmerón Sánchez
Dec 17, 2009·International Journal of Pharmaceutics·Liang ChengShengrong Guo
Nov 12, 2010·The Journal of Family Planning and Reproductive Health Care·Diana Mansour
Jan 1, 2011·ISRN Pharmaceutics·Shailesh T PrajapatiChhagan N Patel
Jul 25, 2012·Molecular Pharmaceutics·Tapan K Dash, V Badireenath Konkimalla
Mar 8, 2013·International Journal of Nanomedicine·Mandula BorjiginEric B Kmiec
Aug 7, 2013·Molecular Pharmaceutics·Beata ChertokRobert Langer
Dec 18, 2013·Journal of Pharmaceutical Sciences·Eneko LarrañetaJosé Ramón Isasi
Dec 2, 2015·International Journal of Pharmaceutics·Eneko LarrañetaRyan F Donnelly
Dec 22, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Henrike HäbelAila Särkkä
Mar 11, 2016·Molecular Pharmaceutics·Kinam Park
Jun 28, 2016·Macromolecular Materials and Engineering·Eneko LarrañetaRyan F Donnelly
May 24, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Rajan Sharma BhattaraiSai H S Boddu
Aug 5, 2017·Materials·Tobias ZehnderAldo R Boccaccini
May 17, 2018·Royal Society Open Science·Asad UllahGyu Man Kim
Nov 13, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Raquel BoiaAna Raquel Santiago
Dec 18, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Luiza SteffensDinara Jaqueline Moura
Mar 25, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Wei-Hsin HsuHsieh-Chih Tsai
Mar 28, 2020·Polymers·Anita Ioana VisanGabriel Socol
Jul 7, 2020·Engineering in Life Sciences·Sandra WittJohanna-Gabriela Walter
Nov 11, 2019·ACS Biomaterials Science & Engineering·Essyrose MathewDimitrios A Lamprou

❮ Previous
Next ❯

Citations

Jan 24, 2021·International Journal of Pharmaceutics·Niamh K MartinEneko Larrañeta
Dec 19, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Juliana C QuartermanAliasger K Salem
Feb 5, 2021·International Journal of Pharmaceutics·Athina LiaskoniClive J Roberts
May 11, 2021·Veterinary Surgery : VS·Richard ShinnJohn Rossmeisl
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Aurelio Salerno, Paolo A Netti
Aug 16, 2021·International Journal of Pharmaceutics·Sarah A StewartEneko Larrañeta

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

An
CTvol
Data Viewer
Cura
CT
OneAttension

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Sílvia Ligório FialhoArmando Silva-Cunha
Journal of Controlled Release : Official Journal of the Controlled Release Society
Raquel BoiaAna Raquel Santiago
© 2021 Meta ULC. All rights reserved