Polycaprolactone Based Nanoparticles Loaded with Indomethacin for Anti-Inflammatory Therapy: From Preparation to Ex Vivo Study

Pharmaceutical Research
Waisudin BadriAbdelhamid Elaissari

Abstract

This work focused on the preparation of polycaprolactone based nanoparticles containing indomethacin to provide topical analgesic and anti-inflammatory effect for symptomatic treatment of inflammatory diseases. Indomethacin loaded nanoparticles are prepared for topical application to decrease indomethacin side effects and administration frequency. Oppositely to already reported works, in this research non-invasive method has been used for the enhancement of indomethacin dermal drug penetration. Ex-vivo skin penetration study was carried out on fresh human skin. Nanoprecipitation was used to prepare nanoparticles. Nanoparticles were characterized using numerous techniques; dynamic light scattering, SEM, TEM, DSC and FTIR. Regarding ex-vivo skin penetration of nanoparticles, confocal laser scanning microscopy has been used. The results showed that NPs hydrodynamic size was between 220 to 245 nm and the zeta potential value ranges from -19 to -13 mV at pH 5 and 1 mM NaCl. The encapsulation efficiency was around 70% and the drug loading was about 14 to 17%. SEM and TEM images confirmed that the obtained nanoparticles were spherical with smooth surface. The prepared nanoparticles dispersions were stable for a period of 30 days under...Continue Reading

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Citations

Feb 8, 2020·Advanced Healthcare Materials·Shasha WangLiming Nie
Mar 28, 2020·Polymers·Anita Ioana VisanGabriel Socol
Dec 8, 2017·Expert Opinion on Pharmacotherapy·Kevin H ManiarC Thomas Vangsness
Jul 7, 2020·Engineering in Life Sciences·Sandra WittJohanna-Gabriela Walter
Aug 25, 2020·Pharmaceutical Research·Natália Helen FerreiraDenise Crispim Tavares
Mar 19, 2019·Organic & Biomolecular Chemistry·Yuxiang ZhouPeijun Liu
Jan 10, 2021·Pharmaceutics·Daniela Placha, Josef Jampilek
Oct 30, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Silvio Almeida JuniorRicardo Andrade Furtado
May 30, 2020·Molecular Pharmaceutics·Mingyue CuiChenjie Xu
Apr 15, 2021·Colloids and Surfaces. B, Biointerfaces·Mohammed Elmowafy

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Methods Mentioned

BETA
nanoprecipitation
dynamic light scattering
Infrared Spectroscopy
biopsies
Scanning Electron Microscopy
PCL

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