PMID: 2501909Jul 3, 1989Paper

Polychlorinated biphenyl (Aroclor 1254) induced changes in femur morphometry calcium metabolism and nephrotoxicity

Toxicology
J E Andrews

Abstract

Experiments were performed to investigate the effects of polychlorinated biphenyl (PCB) on calcium metabolism, femur morphometry, and nephrotoxicity. Male Fischer 344 rats were dosed daily intragastrically (ig) for 5, 10 or 15 weeks with 0, 0.1, 1, 10 or 25 mg PCB/kg body weight. After 5, 10 and 15 weeks, liver weight and liver-to-body weight ratio were increased at the 2 higher dose levels. Overt toxicity was observed at the highest dose level after 10 and 15 weeks as evidenced by significantly smaller body weight. Urinary alkaline phosphatase and lactate dehydrogenase activities were elevated at 5, 10 and 15 weeks of PCB exposure and the kidney-to-body weight ratios were elevated at the 10 and 25 mg/kg dose levels after 10 and 15 weeks of exposure indicating nephrotoxicity. Hypercalcemia was present at the highest dose level after 5 and 10 weeks of exposure but serum calcium concentration was normal at 15 weeks. Serum triglycerides were significantly elevated after 5 weeks of exposure but were significantly decreased after 10 and 15 weeks of PCB exposure. Serum cholesterol was significantly elevated at the 2 higher dose levels at all 3 periods. Femur density was increased at the 10 mg/kg dose level after 5 weeks, at all dose ...Continue Reading

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Citations

Dec 10, 2002·Marine Environmental Research·Madeleine NymanEero Helle
Aug 10, 2007·Journal of Toxicology and Environmental Health. Part a·Glen A FoxG Douglas Campbell
Sep 19, 2008·Journal of Toxicology and Environmental Health. Part a·Glen A FoxP Monica Lind
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Sep 17, 2008·Environmental Health Perspectives·Susan HodgsonLars Jarup
Jun 16, 2015·Marine Pollution Bulletin·Giovanna ScopellitiSalvatrice Vizzini
Nov 25, 2003·Ambio·P Monica LindJan Orberg
Sep 24, 2005·Cell Biochemistry and Function·Selim KutluBayram Yilmaz
Jun 1, 1995·Risk Analysis : an Official Publication of the Society for Risk Analysis·R J Scheuplein, J C Bowers
Sep 8, 2006·Environmental Science & Technology·Alejandro B Rodriguez-NavarroKaren F Gaines

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