Polychlorinated biphenyl-degrading pseudomonads: survival in mouse intestines and competition with normal flora

Journal of Toxicology and Environmental Health
S E GeorgeL Claxton

Abstract

Although naturally occurring and mutant organisms, historically, have been released into the environment for various purposes, health concerns associated with the release of microorganisms have recently resurfaced. Federal agencies have been given the task of reassuring society that any released organisms are not likely to produce adverse health effects. Methods, therefore, for evaluating the potential health effects due to environmental release of mutant and genetically engineered microorganisms are under investigation. A mouse model was developed that examines morbidity, mortality, and more indirect effects such as colonization potential of the intestinal tract, as well as competition with and alteration of the intestinal microbiota populations. The Pseudomonas spp. used in this study were isolated from a commercial product and used for degrading polychlorinated biphenyls. Mice were dosed individually with 10(3), 10(6), and 10(9) colony-forming units of each microorganism. At specific time intervals the intestines were removed and examined for the presence of the dosed microorganism. At the two higher doses, 10(6) and 10(9) colony-forming units, P. maltophilia strain BC6 and two P. aeruginosa strains, BC16 and BC18, were reco...Continue Reading

Citations

Mar 1, 1995·Journal of Toxicology and Environmental Health·R W ChadwickJ Chang
Dec 1, 1994·The Journal of Applied Bacteriology·J ChangC E Autry
Nov 1, 1993·Applied and Environmental Microbiology·S E GeorgeL D Claxton
Jun 1, 1990·Applied and Environmental Microbiology·S E GeorgeL D Claxton

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