Polychlorinated biphenyl quinone metabolites lead to oxidative stress in HepG2 cells and the protective role of dihydrolipoic acid

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Jing LiuYang Song

Abstract

Parent polychlorinated biphenyls (PCBs) have been shown to induce cellular oxidative stress. However, the effects of PCB active metabolites have not been extensively investigated. Parent PCBs are first converted to hydroquinone metabolites via cytochrome P-450-catalyzed hydroxylation, and the hydroquinone metabolites are then further oxidized into the corresponding quinone metabolites. Quinones are responsible for a wide range of toxic effects because of their high reactivity. Previous studies have suggested that reactive oxygen species (ROS) play important roles in multiple toxic mechanisms. In this context, the present study was undertaken to investigate oxidative stress resulting from treatment with PCB quinones in HepG2 cells. The protective effects resulting from co-administration of dihydrolipoic acid (DH-LA) were also investigated. We have found that exposure to PCB quinones leads to: (1) a decrease in cell viability; (2) an increase in both the total ROS production and superoxide production; (3) only 3Cl-PCBQ caused significant increase in the thiobarbituric acid reactive substances (TBARS) level; (4) an increase in SOD activity and a decrease in catalase activity; and (5) a decrease in GST activity and GSH level. We ha...Continue Reading

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Citations

Dec 3, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiaokang ZhuYang Song
Jun 27, 2014·Environmental Research·Diego BadernaEmilio Benfenati
Jun 21, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Erqun SongYang Song
Jul 21, 2016·Chemical Research in Toxicology·Esra MutluJames A Swenberg
Aug 21, 2018·Environmental Science & Technology·Chang WangXing-Fang Li
Feb 11, 2018·Chemosphere·Lais Roberta Deroldo SommaggioMaria Aparecida Marin-Morales

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