Polychlorinated biphenyls affect histone modification pattern in early development of rats: a role for androgen receptor-dependent modulation?

Epigenomics
Lavinia CasatiFabio Celotti

Abstract

The epigenome represents an important target of environmental pollution. Early-life exposure to polychlorinated biphenyls (PCBs) modifies sex steroid enzymes and receptor transcription patterns. Steroid receptors, such as androgen receptor (AR), function as coregulators of histone modification enzymes. To clarify if a PCB early-life exposure might affect the epigenome in rat liver, we analyzed some histone post-translational modifications (H3K4me3 and H4K16Ac) and the corresponding histone remodeling enzymes, and the AR as a histone enzyme coregulator. We observed a decrease of H4K16Ac and H3K4me3 levels, possibly linked to the induction of chromatin-modifying enzymes SirtT1 and Jarid1b, and a decrease of AR. PCBs also seem to induce AR transcriptional activity. Some of the observed effects are sex dimorphic. Our data suggest that an early-life exposure to PCB sometimes modifies the epigenome in the offspring liver in a dimorphic way. AR might be involved in modulating PCB effects on the epigenome.

References

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Citations

Jun 3, 2014·Current Environmental Health Reports·Guoying WangXiaobin Wang
Feb 18, 2014·Endocrine-related Cancer·Kevin C KnowerColin D Clyne
Jan 26, 2013·Current Opinion in Cell Biology·Tanja Waldmann, Robert Schneider
Aug 3, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Lavinia CasatiFabio Celotti
Jan 24, 2017·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Sara E Wirbisky, Jennifer L Freeman
Oct 4, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Neelakanteswar AluruLilah Glazer
Nov 18, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Ross GilletteDavid Crews
Feb 28, 2017·Genes & Nutrition·Daniele MarcocciaMaria Marino
Nov 30, 2018·International Journal of Environmental Research and Public Health·Kun ZhouYankai Xia
Jun 23, 2020·Oncology Letters·Gloria M CalafTammy C Bleak
Feb 10, 2021·International Journal of Environmental Research and Public Health·Saira AmirAristidis Tsatsakis

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Methods Mentioned

BETA
PCR
immunoprecipitation
transfection
acetylation
electrophoresis
ChIP

Software Mentioned

Primer3
methyl primer express

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