Polychlorinated biphenyls and their association with survival following breast cancer

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Humberto ParadaMarilie D Gammon

Abstract

Polychlorinated biphenyls (PCBs) are hypothesised to influence breast carcinogenesis due to their persistence and potential to induce oestrogenic and anti-oestrogenic effects. Whether PCBs influence survival following breast cancer is unknown. A population-based cohort of women diagnosed with first primary invasive or in situ breast cancer in 1996-1997 and with blood-measured PCBs (n=627) collected shortly after diagnosis was followed for vital status through 2011. After 5 and 15 years, we identified 54 and 187 deaths, respectively, of which 36 and 74 were breast cancer related. Using Cox regression, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality for baseline PCB concentrations, individually and as oestrogenic (ΣGroup 1B: PCB101, PCB174, PCB177, PCB187, and PCB199), anti-oestrogenic (ΣGroup 2A: PCB66, PCB74, PCB105, and PCB118; ΣGroup 2B: PCB138 and PCB170), and cytochrome P450 enzyme-inducing (ΣGroup 3: PCB99, PCB153, PCB180, PCB183, and PCB203) groups. The highest PCB174 tertile was associated with an increase in all-cause (HR=2.22, 95% CI: 1.14-4.30) and breast cancer-specific (HR=3.15, 95% CI: 1.23-8.09) mortalities within 5 years of diagnosis and remained associated with breast cancer-spe...Continue Reading

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Citations

Mar 5, 2017·Molecular and Cellular Endocrinology·Marzia Di DonatoGabriella Castoria
Jun 23, 2020·Oncology Letters·Gloria M CalafTammy C Bleak
Nov 25, 2020·Environmental Health : a Global Access Science Source·Daisuke OnozukaMasutaka Furue
Apr 11, 2020·International Journal of Hygiene and Environmental Health·Humberto ParadaMelissa A Troester
May 1, 2021·International Journal of Molecular Sciences·Li-Hsuan WangKuo-Hu Chen

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