PMID: 8950306Jan 1, 1996Paper

Polychlorinated biphenyls release insulin from RINm5F cells

Life Sciences
L J FischerM A Wagner

Abstract

Polychlorinated biphenyls (PCBs) possess a variety of biological effects, including alterations in growth, development and metabolism, that may be dependent on insulin. However, no reports on the action of PCBs on cells which produce and secrete insulin are available. The current study examined the ability of a commercial mixture of PCBs (Aroclor 1254) and three specific PCB congeners, to alter the release of insulin using the hormone producing cell line RINm5F. Exposure of cells to Aroclor 1254 (A-1254) produced a concentration-dependent increase in media insulin reaching a peak, when expressed as percent of control, at 30 min. In spite of continued exposure, media insulin relative to control declined and no treatment-related difference was observed at 48 hrs. Cellular levels of the hormone declined as much as 50% by that time. The insulin releasing action of A-1254 was mimicked by each of the non-coplanar congeners 2,2',4,4'-tetrachlorobiphenyl (TCB) and 2,2',4,4',5,5'-hexachlorobiphenyl (HCB) but the coplanar congener 3,3',4,4'-TCB showed no significant activity. These results indicate that PCBs are capable of producing a release of insulin from RINm5F cells, an effect that is unlikely to be associated with coplanar congener...Continue Reading

References

Mar 1, 1992·Journal of Cellular Biochemistry·A E Boyd
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Citations

Apr 24, 2014·Current Diabetes Reports·Andrew G Kirkley, Robert M Sargis
Oct 6, 2012·Drug and Chemical Toxicology·Anne Augustine WilliamsKarundevi Balasubramanian
Sep 18, 2001·Toxicology and Applied Pharmacology·D ColettiS Adamo
May 26, 2001·Diabetes Care·M P LongneckerUNKNOWN Collaborative Perinatal Project (CPP)
Jul 12, 2016·International Journal of Hygiene and Environmental Health·André EsserThomas Kraus
Oct 21, 2016·Reproductive Toxicology·Jerrold J HeindelFrederick Vom Saal
Oct 25, 2017·International Journal of Environmental Research and Public Health·Demetrios PetrakisAristides M Tsatsakis
Dec 4, 2010·Journal of Environmental Monitoring : JEM·Charles Jay EverettMarty Player
Jun 9, 2018·Journal of Occupational Medicine and Toxicology·Sahar EftekhariAndré Esser

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