Polychromatic LED in oval full-thickness wound healing in non-diabetic and diabetic rats

Photomedicine and Laser Surgery
Farouk A H Al-Watban, Bernard L Andres

Abstract

Our goal was to determine the efficacy of polychromatic light-emitting diode (LED) in the enhancement of wound healing in non-diabetic and diabetic rats. LEDs are increasingly used as an alternative light source for phototherapy. A cluster of 25 LED photons at 510-543, 594-599, 626-639, 640-670, and 842-872 nm wavelengths with 272-mW output power was used. Male Sprague-Dawley rats (n = 61) were randomly assigned into non-diabetic and diabetic groups and into light treatment groups, that is, control, 5, 10, 20, and 30 J/cm(2). Streptozotocin was used for diabetes induction. Wounds were created using a scalpel after 1 week of wounding. Wounds were measured daily and plotted in time, and the trendline was fitted to obtain slope values. Relative wound healing percentage was computed as follows: RWH% = [(Slope treated - Slope control)/(Slope control)] x 100. The t-test (alpha = 0.05) was used for analysis. The RWH% in the non-diabetic rats was insignificant (p > 0.05) at 5, 10, 20, and 30 J/cm(2) treatments, giving 4.3 +/- 1.97%, 5.4 +/- 1.94%, 4.5 +/- 1.96%, and 1.2 +/- 2.03%, respectively. The healing of diabetic rats was significantly impaired by -11.7 +/- 3.25% (p = 0.02), which was mitigated by 5 J/cm(2) treatment (2.4 +/- 3.02...Continue Reading

References

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Nov 13, 2001·Lasers in Medical Science·F A al-Watban, B L Andres
Jan 22, 2002·Journal of Clinical Laser Medicine & Surgery·F A Al-Watban, B L Andres
Jul 10, 2002·Experimental Dermatology·László VirágCsaba Szabó
Dec 4, 2003·Journal of Clinical Laser Medicine & Surgery·Farouk A H Al-Watban, Bernard L Andres

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Citations

Dec 17, 2009·Photomedicine and Laser Surgery·Ana Paula Cavalcanti de SousaAntônio L B Pinheiro
Dec 29, 2009·Photomedicine and Laser Surgery·Antonio L B Pinheiro
Jun 18, 2014·Journal of Photochemistry and Photobiology. B, Biology·Antonio Luiz B PinheiroLandulfo Silveira
Mar 3, 2012·The Annals of Thoracic Surgery·Christian A PlassAlexander M Prusa
Oct 27, 2015·Lasers in Medical Science·Paula Kariluce de CarvalhoAntonio Balbin Villaverde
Feb 17, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Xingjia WuJuanita Anders
Feb 11, 2014·Clinical Implant Dentistry and Related Research·Paulo Esteves Pinto FariaLuiz Antonio Salata
May 21, 2011·Photomedicine and Laser Surgery·Ana Paula Cavalcanti de SousaAntônio Luiz Barbosa Pinheiro
Jun 29, 2006·Journal of Magnetic Resonance Imaging : JMRI·Osama Al-KwifiGraham A Wright
Jan 19, 2019·International Journal of Molecular Sciences·Rachel Lai-Chu KwanGladys Lai-Ying Cheing
Jan 5, 2021·The International Journal of Lower Extremity Wounds·Jarosław PasekGrzegorz Cieślar

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