PMID: 6973374Apr 1, 1981Paper

Polyclonal activation of B-lymphocytes by synthetic polyelectrolytes

Biulleten' eksperimental'noĭ biologii i meditsiny
R V PetrovS G Zavgorodniĭ

Abstract

A study was made of the ability of polyacrylic acid, poly-4-vinylpyridine, and the copolymers 4-vinylpyridine and 4-vinyl-N-alkylpyridinium bromides with side hydrocarbonic radicals of varying length to induce in mice of different strains B-cell differentiation into the plaque-forming cells without antigenic stimulation. The polyelectrolytes have been shown to favour the transformation of B lymphocytes to the cells that secrete polyclonal antibodies, i.e. to be polyclonal activators of B lymphocytes. B lymphocyte differentiation induced by the polyelectrolytes does not depend on T cells and is liable to genetic restriction.

References

Jan 1, 1975·Biochemical Society Transactions·G P ArchboldF H Malpress
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Apr 26, 1963·Science·N K Jerne, A A Nordin

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Citations

Sep 1, 1985·Neuroscience and Behavioral Physiology·B A Frolov, S N Afonina
May 1, 1984·Biulleten' eksperimental'noĭ biologii i meditsiny·R I Ataullakhanov
Jun 17, 2009·Bulletin of Experimental Biology and Medicine·D G Deryabin, I F Karimov
Jul 20, 2005·Bulletin of Experimental Biology and Medicine·N V RyazantsevaE A Piguzova
Nov 1, 2012·Bulletin of Experimental Biology and Medicine·N I GabrielyanN L Vologodskaya
Jun 3, 2015·Bulletin of Experimental Biology and Medicine·T V PolezhaevaO N Solomina

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