PMID: 2107509Feb 1, 1990Paper

Polyclonal activation of B lymphocytes during experimental infection with Schistosoma mansoni

Parasitology
L M LopesN M Vaz

Abstract

A significant polyclonal activation of B lymphocytes was observed during experimental infection of C57BL/10J mice with Schistosoma mansoni. The isotypic pattern of this expansion, assessed by the Protein-A plaque-forming cell method, was compared with and found to differ from those occurring after infection by Trypanosoma cruzi or injection of bacterial LPS. In the infection of S. mansoni an early expansion of most immunoglobulin isotypes occurs together with a late, sustained expansion of IgG1-secreting cells. High levels of polyclonal B cell activation were observed after adoptive transfer of spleen cells from infected mice to isogenic recipients pre-treated with hydroxyurea.

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Citations

Jan 2, 2004·Journal of Bacteriology·Isabel Veiga-MaltaArnaldo Videira
Aug 17, 2021·Frontiers in Cellular and Infection Microbiology·Monrat Chulanetra, Wanpen Chaicumpa

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