PMID: 6974218Sep 1, 1981Paper

Polyclonal activation of human B lymphocytes by Fc fragments. I. Characterization of the cellular requirements for Fc fragment-mediated polyclonal antibody secretion by human peripheral blood B lymphocytes

The Journal of Experimental Medicine
E L Morgan, W O Weigle

Abstract

Fc fragments derived from human immunoglobulin were found to be capable of inducing both a proliferative and polyclonal antibody response in human peripheral blood lymphocyte cultures. The cell population proliferating in response to Fc fragments belongs to the B cell lineage. Expression of polyclonal antibody formation requires the presence of both adherent monocytes and T cells. The role of the monocyte is to enzymatically cleave the Fc fragment into 19,000 mol wt Fc subfragments that are then able to induce polyclonal antibody secretion. Stimulation of polyclonal antibody production by Fc subfragments occurs in the absence of adherent monocytes but still requires the presence of T cells.

References

Jan 1, 1976·Journal of Immunological Methods·H M Dosch, E W Gelfand
Jul 1, 1977·The Journal of Experimental Medicine·M A Berman, W O Weigle
Aug 1, 1979·The Journal of Experimental Medicine·E L Morgan, W O Weigle
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A S Fauci, K R Pratt
Jan 1, 1976·International Archives of Allergy and Applied Immunology·J BrochierJ P Revillard
Jan 1, 1975·Transplantation Reviews·G Janossy, M Greaves
Aug 1, 1974·Journal of Immunological Methods·I A Ly, R I Mishell
Jan 1, 1980·The Journal of Experimental Medicine·E L Morgan, W O Weigle
Jul 1, 1980·Cellular Immunology·J PasswellE Merler

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Citations

Jan 1, 1984·Folia Microbiologica·L Fornůsek, V Vĕtvicka
Mar 1, 1983·Molecular Immunology·M VandenbrandenJ M Ruysschaert
Dec 1, 1986·Immunopharmacology·E L MorganM V Hobbs
Aug 1, 1990·Journal of Neuroimmunology·E L MorganJ A Janda
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E L MorganW O Weigle
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R PalaciosK Guy
Jul 1, 1985·The Journal of Experimental Medicine·C M BaumJ M Davie
Nov 1, 1991·Annals of the Rheumatic Diseases·J K Kalsi, N D Hall
Jul 1, 1983·The Journal of Clinical Investigation·R I FoxF V Howell
Jan 1, 1984·Scandinavian Journal of Immunology·E Beckmann, D Levitt
Aug 1, 1984·Scandinavian Journal of Immunology· Lê Thi Bich-Thuy, J P Revillard
Nov 1, 1986·Immunological Investigations·E L MorganW O Weigle
Sep 30, 1982·Journal of Immunological Methods·C L Reading

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